Evidence map›Paper›PMID 35812040›Full record

ArticleAmerican journal of cancer research2022

The homeostatic malfunction of a novel feedback pathway formed by lncRNA021545, miR-330-3p and epiregulin contributes in hepatocarcinoma progression via mediating epithelial-mesenchymal transition.

Siwen Yang, Yunkun Zhang, Chunmei Guo, Rui Liu, Maroua Elkharti, Zhenhua Ge, Qinlong Liu, Shuqing Liu, Ming-Zhong Sun

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Siwen YangCollege of Basic Medical Sciences, Dalian Medical University Dalian, Liaoning, China.
Yunkun ZhangCollege of Basic Medical Sciences, Dalian Medical University Dalian, Liaoning, China.
Chunmei GuoCollege of Basic Medical Sciences, Dalian Medical University Dalian, Liaoning, China.
Rui LiuCollege of Basic Medical Sciences, Dalian Medical University Dalian, Liaoning, China.
Maroua ElkhartiCollege of Basic Medical Sciences, Dalian Medical University Dalian, Liaoning, China.
Zhenhua GeCollege of Basic Medical Sciences, Dalian Medical University Dalian, Liaoning, China.
Qinlong LiuDepartment of General Surgery, The Second Affiliated Hospital, Dalian Medical University Dalian, Liaoning, China.
Shuqing LiuCollege of Basic Medical Sciences, Dalian Medical University Dalian, Liaoning, China.
Ming-Zhong SunCollege of Basic Medical Sciences, Dalian Medical University Dalian, Liaoning, China.
Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A better understanding of tumor metastasis is urgently required for the treatment and prognosis of hepatocarcinoma patients. Current work contributes a novel ceRNA feedback regulation pathway composed of epiregulin (EREG), microRNA-330-3p (miR-330-3p) and long non-coding RNA 021545 (lncRNA021545) in regulating hepatocarcinoma malignancy via epithelial-mesenchymal transition (EMT) process. Closely correlated, the deficiencies of EREG and lncRNA021545 and the overexpression of miR-330-3p were involved in the clinical progression of hepatocarcinoma.

Indexed as

EMTEREGHepatocarcinomalncRNA021545miR-330-3p

Identifiers

PMID35812040
PMCPMC9251696
OpenAlexW4285033065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.