ArticleNature computational science2021
Cluster learning-assisted directed evolution.
Article in Nature computational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Sequence-free landscape inference for directed evolution.PLoS computational biology · 2026Article
- A review of recent advances in generative artificial intelligence models for biomolecular sciences.Acta pharmaceutica Sinica. B · 2026Review
- Active learning-guided optimization of cell-free biosensors for lead testing in drinking water.Nature communications · 2025Article
- Quantified Dynamics-Property Relationships: Data-Efficient Protein Engineering with Machine Learning of Protein Dynamics.Journal of chemical information and modeling · 2025Article
- Semirational Protein Engineering Yields Archaerhodopsin-3-Based Fluorescent Genetically Encoded Voltage Indicators with Enhanced Brightness and Red Shifted Absorption Bands.Chem & bio engineering · 2025Article
- Engineering CAR-T Therapeutics for Enhanced Solid Tumor Targeting.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- A review of transformer models in drug discovery and beyond.Journal of pharmaceutical analysis · 2025Review
- Integrating protein language models and automatic biofoundry for enhanced protein evolution.Nature communications · 2025Article
- Active learning-assisted directed evolution.Nature communications · 2025Article
- Do protein language models learn phylogeny?Briefings in bioinformatics · 2024Article
- A combinatorially complete epistatic fitness landscape in an enzyme active site.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Computer-aided rational design strategy based on protein surface charge to improve the thermal stability of a novel esterase from Geobacillus jurassicus.Biotechnology letters · 2024Article
- Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering.ACS central science · 2024Review
- Multi-Modal CLIP-Informed Protein Editing.Health data science · 2024Article
- Engineering Enzymes for Environmental Sustainability.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023Review
- Engineering Enzymes for Environmental Sustainability.Angewandte Chemie (International ed. in English) · 2023Review
- Artificial intelligence-aided protein engineering: from topological data analysis to deep protein language models.Briefings in bioinformatics · 2023Review
- Article
- Machine Learning for Protein Engineering.ArXiv · 2023Article
- SVSBI: sequence-based virtual screening of biomolecular interactions.Communications biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Directed evolution, a strategy for protein engineering, optimizes protein properties (i.e., fitness) by expensive and time-consuming screening or selection of large mutational sequence space. Machine learning-assisted directed evolution (MLDE), which screens sequence properties
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.