Evidence map›Paper›PMID 35811716›Full record

ArticleFrontiers in cardiovascular medicine2022

Treatment of Hyperlactatemia in Acute Circulatory Failure Based on CO

Vincenza Caruso, Guillaume Besch, Maxime Nguyen, Sebastien Pili-Floury, Belaid Bouhemad, Pierre-Grégoire Guinot, Lactel Study Group

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05032521 (Treatment of Hyperlactatemia in Acute Circulatory Failure Based on Analysis of CO2), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05032521 phase4completednot on this map

Treatment of Hyperlactatemia in Acute Circulatory Failure Based on Analysis of CO2: a Prospective Randomized Superiority Study (The LACTEL Study)

TypeinterventionalSponsorCentre Hospitalier Universitaire DijonRan2021 to 2023Enrolled180ConditionsHyperlactatemia, Actue Circulatory FailureArmscollection of biological data, collection of demographic, ventilatory, cardiac echocardiography, arterial and venous gas data, Standard treatment, stratified treatment according to algorithm
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Lactate and COFrontiers in cardiovascular medicine · 2025
    Article
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vincenza CarusoAnaesthesiology and Critical Care Department, Dijon Bourgogne University Hospital, Dijon, France.
Guillaume BeschDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Besançon, Besançon, France.
Maxime NguyenAnaesthesiology and Critical Care Department, Dijon Bourgogne University Hospital, Dijon, France.
Sebastien Pili-FlouryDepartment of Anesthesiology and Intensive Care Medicine, University Hospital of Besançon, Besançon, France.
Belaid BouhemadAnaesthesiology and Critical Care Department, Dijon Bourgogne University Hospital, Dijon, France.
Pierre-Grégoire GuinotAnaesthesiology and Critical Care Department, Dijon Bourgogne University Hospital, Dijon, France.
Lactel Study Group
Université de Bourgogne · FRCentre Hospitalier Universitaire de Besançon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hyperlactatemia is a biological marker of tissue hypoperfusion with well-known diagnostic, prognostic, and therapeutic implications in shock states. In daily clinical practice, it is difficult to find out the exact mechanism underlying hyperlactatemia. Central venous to arterial CO Methods: LACTEL is a randomized, prospective, multicentric, controlled study. It compares the treatment of hyperlactatemia using an algorithm based on the pCO Discussion: pCO Clinical Trial Registration: www.clinicaltrials.gov; identifier: NCT05032521.

Indexed as

acute circulatory failureanaerobic metabolismcardiac surgery shockhyperlactatemialactic acidosispCO2 gapresuscitationsepsis

Identifiers

PMID35811716
PMCPMC9260150
OpenAlexW4283452299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.