ArticleFrontiers in cardiovascular medicine2022
Isolating the Effect of Arch Architecture on Aortic Hemodynamics Late After Coarctation Repair: A Computational Study.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- The Correlates of Recoarctation After Repair in Pediatric Patients with Aortic Coarctation: A Real-World Descriptive Study.Journal of clinical medicine · 2026Article
- An in silico analysis of heart rate impact on wall shear stress hemodynamic parameters in aortic coarctation.Scientific reports · 2025Article
- A systematic quantification of hemodynamic differences persisting after aortic coarctation repair.Frontiers in bioengineering and biotechnology · 2025Article
- Coarctation of the Aorta: Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2023Review
- Using computed tomography angiography and computational fluid dynamics to study aortic coarctation in different arch morphologies.Frontiers in pediatrics · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Objectives: Effective management of aortic coarctation (CoA) affects long-term cardiovascular outcomes. Full appreciation of CoA hemodynamics is important. This study aimed to analyze the relationship between aortic shape and hemodynamic parameters by means of computational simulations, purposely isolating the morphological variable. Methods: Computational simulations were run in three aortic models. MRI-derived aortic geometries were generated using a statistical shape modeling methodology. Starting from Results: Comparing no-CoA and CoA revealed substantial differences in all hemodynamic parameters. However, simulations revealed significant increases in vorticity at the site of CoA repair, higher WSS in the descending aorta and a 12% increase in power loss, in r-CoA compared to no-CoA, despite no clinically significant narrowing (CoA index >0.8) in the r-CoA model. Conclusions: Small alterations in aortic morphology impact on key hemodynamic indices. This may contribute to explaining phenomena such as persistent hypertension in the absence of any clinically significant narrowing. Whilst cardiovascular events in these patients may be related to hypertension, the role of arch geometry may be a contributory factor.
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Registered trials
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