ArticleFrontiers in cardiovascular medicine2022
C-reactive Protein Elevation Is Associated With QTc Interval Prolongation in Patients Hospitalized With COVID-19.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Inflammatory Biomarkers and ECG Repolarization Metrics: Sudden Death in Heart Failure With Reduced Ejection Fraction.JACC. Advances · 2026Article
- Proteomic Profiling of COVID-19 Patients Sera: Differential Expression with Varying Disease Stage and Potential Biomarkers.Diagnostics (Basel, Switzerland) · 2024Article
- Cardiovascular effects of the post-COVID-19 condition.Nature cardiovascular research · 2024Review
- Article
- Association between corrected QT interval and long-term cardiovascular outcomes in elderly patients who had undergone endovascular therapy for lower extremity arterial disease.Frontiers in cardiovascular medicine · 2023Article
- The natural history of QTc interval and its clinical impact in coronavirus disease 2019 survivors after 1 year.Frontiers in cardiovascular medicine · 2023Article
- Analysis of risk factors and short-term prognostic factors of arrhythmia in patients infected with mild/moderate SARS-CoV-2 Omicron variant.Frontiers in medicine · 2023Article
- The Diagnostic Value of Inflammatory Markers (CRP, IL6, CRP/IL6, CRP/L, LCR) for Assessing the Severity of COVID-19 Symptoms Based on the MEWS and Predicting the Risk of Mortality.Journal of inflammation research · 2023Article
- QT Interval Prolongation Is a Novel Predictor of 1-Year Mortality in Patients With COVID-19 Infection.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
10 authors.
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Abstract
Background: The relationship between inflammation and corrected QT (QTc) interval prolongation is currently not well defined in patients with COVID-19. Objective: This study aimed to assess the effect of marked interval changes in the inflammatory marker C-reactive protein (CRP) on QTc interval in patients hospitalized with COVID-19. Methods: In this retrospective cohort study of hospitalized adult patients admitted with COVID-19 infection, we identified 85 patients who had markedly elevated CRP levels and serial measurements of an ECG and CRP during the same admission. We compared mean QTc interval duration, and other clinical and ECG characteristics between times when CRP values were high and low. We performed mixed-effects linear regression analysis to identify associations between CRP levels and QTc interval in univariable and adjusted models. Results: Mean age was 58 ± 16 years, of which 39% were women, 41% were Black, and 25% were White. On average, the QTc interval calculated Conclusion: An interval QTc interval prolongation is observed with a marked elevation in CRP levels in patients with COVID-19.
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