Evidence map›Paper›PMID 35811672›Full record

ArticleFrontiers in cellular and infection microbiology2022

Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of

Youliang Ren, Thomas Xue, Joshua Rainbolt, Karen L de Mesy Bentley, Chad A Galloway, Yuting Liu, Philip Cherian, Jeffrey Neighbors, Marloes I Hofstee, Frank H Ebetino and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. MRSA-dominant colonization and synergistic pathogenicity withJournal of orthopaedic translation · 2026
    Article
  2. Osteomyelitis.Nature reviews. Disease primers · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Bisphosphonate-Conjugated Sitafloxacin for Treatment ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  7. Immune escape ofFrontiers in cellular and infection microbiology · 2025
    Review
  8. Antibacterial Mechanisms and Clinical Impact of Sitafloxacin.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  9. Article
  10. Review
  11. IntracellularHeliyon · 2024
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Youliang RenCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States.
Thomas XueCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States.
Joshua RainboltCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States.
Karen L de Mesy BentleyCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States.
Chad A GallowayDepartment of Pathology, University of Rochester Medical Center, Rochester, NY, United States.
Yuting LiuCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States.
Philip CherianBioVinc LLC, Pasadena, CA, United States.
Jeffrey NeighborsBioVinc LLC, Pasadena, CA, United States.
Marloes I HofsteeAO Research Institute Davos, Davos Platz, Switzerland.
Frank H EbetinoBioVinc LLC, Pasadena, CA, United States.
Thomas Fintan MoriartyAO Research Institute Davos, Davos Platz, Switzerland.
Shuting SunBioVinc LLC, Pasadena, CA, United States.
Edward M SchwarzCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States.
Chao XieCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States.
University of Rochester Medical Center · USBioVinc (United States) · USAO Foundation · CH

Funding

Project 2: Defining the Protective vs. Susceptible Immune Proteome of S. aureus OsteomyelitisP50AR072000 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2017 to 2026
$13.6M
Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Bone targeted delivery of an antimicrobial drug for osteomyelitis therapyR44AI125060 · NIAID · BIOVINC, LLC · PI EBETINO, FRANK H. · 2020 to 2022
$3.0M
NIAID NIH HHS R44 AI125060NIAMS NIH HHS P30 AR069655NIAMS NIH HHS P50 AR072000
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Methicillin-Resistant Staphylococcus aureusOsteomyelitisStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsDiphosphonatesDisease Models, AnimalFluoroquinolonesMiceStaphylococcus aureusTissue DistributionVancomycinAnti-Bacterial AgentsDiphosphonatesFluoroquinolonessitafloxacinVancomycinantibioticbisphosphonateosteomyelitisStaphylococcus aureustransmission electron microscopy

Identifiers

PMID35811672
PMCPMC9263620
OpenAlexW4283370592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.