ArticleJournal of pharmaceutical analysis2022
MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography.
Article in Journal of pharmaceutical analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 42 citations in OpenAlex.
- Chiral Separations by Using Capillary Electrochromatography: An Overview.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Development and application of chiral separation technology based on chiral metal-organic frameworks.Journal of pharmaceutical analysis · 2025Review
- Synergistic enantioseparation system based on a novel nanomaterial synthesized by chiral metal-organic framework and chiral molecularly imprinted polymer in capillary electrochromatography.Mikrochimica acta · 2024Article
- Preparation and study of a capillary electrochromatographic column prepared by conjugating β-CD COFs and gold-poly glycidyl methacrylate nanoparticles.Mikrochimica acta · 2024Article
- An Fe-Cu bimetallic organic framework as a microwave sensitizer for treating tumors using combined microwave thermotherapy and chemodynamic therapy.Journal of pharmaceutical analysis · 2024Article
- Enantiomeric analysis of chiral phenyl aromatic compounds by coated capillary electrochromatography based on a MOF-on-MOF stationary phase.Mikrochimica acta · 2024Article
- [Research progress on the construction and applications of metal-organic frameworks in chromatographic stationary phases].Se pu = Chinese journal of chromatography · 2023Article
- Dual-ligand 3D lammelar chiral metal-organic framework for capillary electrochromatographic enantioseparations.Mikrochimica acta · 2023Article
- A chiral metal-organic framework {(HQA)(ZnClJournal of pharmaceutical analysis · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homochiral metal-organic frameworks (MOFs) have attracted considerable attention in many fields of research, such as chiral catalysis and chiral chromatography. However, only few homochiral MOFs can be effectively used in capillary electrochromatography (CEC) and their performances are far from adequate. In this study, we successfully synthesized achiral nanocrystalline MIL-53. A facile post-synthetic modification strategy was then implemented to functionalize the product, yielding a homochiral MOF: l-His-NH-MIL-53. This MOF was then employed as a chiral coating in open-tubular CEC mode (OT-CEC), and, as such, it exhibited high enantioselectivities for several racemic drugs. The homochiral MOF and the fabricated capillary coating were systematically characterized using transmission electron microscopy, scanning electron microscopy (with energy-dispersive X-ray spectrometry), Fourier-transform infrared spectroscopy, X-ray diffractometry, thermogravimetric analysis, circular dichroism spectroscopy, Brunauer-Emmett-Teller surface area measurements, and X-ray photoelectron spectroscopy. This study is expected to provide a new strategy for the design and establishment of MOF-based chiral OT-CEC systems.
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