Evidence map›Paper›PMID 35811540›Full record

ArticleJournal of neonatal-perinatal medicine2022

Clinical outcomes and gestational age based prediction of pneumatosis intestinalis in preterm infants with necrotizing enterocolitis.

P M Garg, J L Paschal, M A Y Ansari, H Sonani, C Grey, S Chan, N Varshney, W Hillegass

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neonatal-perinatal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. [Ultrasound diagnosis of necrotizing enterocolitis in neonates].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

P M GargDepartment of Pediatrics/Neonatology, University of Mississippi, Jackson, MS, USA.
J L PaschalDepartment of Pediatrics/Neonatology, University of Mississippi, Jackson, MS, USA.
M A Y AnsariDepartment of Data Science, University of Mississippi, Jackson, MS, USA.
H SonaniDepartments of Pathology, University of Mississippi, Jackson, MS, USA.
C GreyDepartments of Pathology, University of Mississippi, Jackson, MS, USA.
S ChanDepartments of Radiology, Children's Mercy Hospital, Kansas City, MO, USA.
N VarshneyDepartments of Pathology, University of Mississippi, Jackson, MS, USA.
W HillegassDepartment of Medicine, University of Mississippi, Jackson, MS, USA.
University of Mississippi · USChildren's Mercy Hospital · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

backgroundTo determine the clinical implications and gestation age-specific diagnostic predictability of pneumatosis in preterm infants with necrotizing enterocolitis (NEC).

methodsA retrospective study on abdominal radiographs comparing clinical and radiological information in infants with and without pneumatosis.

resultOur findings disproved our hypothesis. Pneumatosis was seen more frequently in infants with higher gestational age [28.4 (26.1-32.4) vs. 26.4 (24.3-29) weeks; p < 0.001] and birth weight [1110 (762-1768) vs. 770 (645-1022) grams; p < 0.001] and were more likely delivered vaginally (39.1% vs. 21.7%, p = 0.01). Portal venous gas was seen frequently on radiographs (10.3% vs. 0%, p < 0.001), but not pneumoperitoneum (20.7% vs. 36.7%, p = 0.02). Infants with pneumatosis frequently developed acute kidney injury, with higher serum creatinine (16.5% vs. 4.5%, p = 0.02) and frequent oliguria (12.9% vs. 2.7 %; p = 0.043) and had higher C-reactive protein levels at 24 and 96 hours (p < 0.002). Receiver operating curves for pneumatosis showed GA >28 weeks and birth weight > 1000 gm to have a sensitivity of 58.6% and specificity of 72.5%.

conclusionContrary to our hypothesis, infants who developed pneumatosis during NEC were more mature with a higher gestational age and birth weight than those who did not.

Indexed as

Enterocolitis, NecrotizingFetal DiseasesInfant, Newborn, DiseasesBirth WeightFemaleGestational AgeHumansInfantInfant, NewbornInfant, PrematureRetrospective StudiesClinical outcomesnecrotizing enterocolitispneumatosispreterm infant

Identifiers

PMID35811540
PMCPMC10311076
OpenAlexW4284683411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.