Evidence map›Paper›PMID 35811373›Full record

ArticlePsychological medicine2023

Genetic liability to posttraumatic stress disorder and its association with postpartum depression.

Kathrine Bang Madsen, Xiaoqin Liu, Clara Albiñana, Bjarni Jóhann Vilhjálmsson, Esben Agerbo, Preben Bo Mortensen, David Michael Hougaard, Merete Nordentoft, Thomas Werge, Ole Mors and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Kathrine Bang MadsenNCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-0103-5534
Xiaoqin LiuNCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
Clara AlbiñanaNCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
Bjarni Jóhann VilhjálmssonNCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
Esben AgerboNCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
Preben Bo MortensenNCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
David Michael HougaardiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Merete NordentoftiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Thomas WergeiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Ole MorsiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Anders D BørglumiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Trine Munk-OlsenNCRR - National Centre for Register-based Research, Business and Social Sciences, Aarhus University, Aarhus, Denmark.
Aarhus University · DKUniversity of Copenhagen · DKAarhus University Hospital · DKStatens Serum Institut · DKUniversity of Southern Denmark · DK

Funding

5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9M
NIMH NIH HHS U01 MH109514
6 · The paper itself

Abstract

backgroundChildbirth may be a traumatic experience and vulnerability to posttraumatic stress disorder (PTSD) may increase the risk of postpartum depression (PPD). We investigated whether genetic vulnerability to PTSD as measured by polygenic score (PGS) increases the risk of PPD and whether a predisposition to PTSD in PPD cases exceeds that of major depressive disorder (MDD) outside the postpartum period.

methodsThis case-control study included participants from the iPSYCH2015, a case-cohort of all singletons born in Denmark between 1981 and 2008. Restricting to women born between 1981 and 1997 and excluding women with a first diagnosis other than depression (

resultsThe PTSD PGS was significantly associated with PPD (OR 1.42, 95% CI 1.20-1.68 per standard deviation increase in PTSD PGS) compared to healthy female controls. Genetic PTSD vulnerability in PPD cases did not exceed that of matched female depression cases outside the postpartum period (OR 1.10, 95% CI 0.94-1.30 per standard deviation increase).

conclusionsGenetic vulnerability to PTSD increased the risk of PPD but did not differ between PPD cases and women with depression at other times.

Indexed as

Depression, PostpartumMajor Depressive DisorderStress Disorders, Post-TraumaticCase-Control StudiesFemaleHumansInfant, NewbornPostpartum PeriodRisk FactorsChildbirthgeneticspostpartum depressionposttraumatic stress disorder

Identifiers

PMID35811373
PMCPMC10782827
OpenAlexW4285014157

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.