ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
A Neuroimaging Signature of Cognitive Aging from Whole-Brain Functional Connectivity.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Advances in gait research related to Alzheimer's disease.Frontiers in neurology · 2025Pooled it
- Individual neural dynamics of successful Gamma neuromodulation through EEG-neurofeedback in the aging brain.Scientific reports · 2025Trial
- Hierarchical disruption of lateral prefrontal cortex gradients in cognitive aging.GeroScience · 2026Article
- Functional Brain Network Predictors of Abstinence Treatment Outcomes in Methamphetamine Use Disorder.CNS neuroscience & therapeutics · 2026Article
- Connectome-based spatial statistics enabling large-scale population analyses of human connectome across cohorts.bioRxiv : the preprint server for biology · 2026Article
- Socioeconomic status and intrinsic capacity trajectories among middle-aged and older adults in China: mediating role of cognitive leisure activities.The journal of nutrition, health & aging · 2026Article
- Prenatal Cannabis Exposure Shaping Altered Brain Connectivity: Neural Correlates of Cognitive and Mental Health Variability in Offspring.Research square · 2026Article
- Frontal Vulnerability versus Temporal Resilience within the Core Language Network: Neuro-compensatory Mechanisms Underline Differential Language Aging Trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Individual identifiability following Procrustes alignment of functional gradients: effect of subspace dimensionality.Communications biology · 2026Article
- Sleep and Subjective Age: A Narrative Review of Epidemiological Evidence, Underlying Mechanisms, and Population Differences.Nature and science of sleep · 2026Review
- Associations between leisure activities with trajectories of intrinsic capacity among Chinese older adults: the China health and retirement longitudinal study.Archives of public health = Archives belges de sante publique · 2025Article
- Plasma biomarkers as core mediators in functional network abnormalities: Evidence from a two-cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population.Molecular psychiatry · 2025Article
- Characterizing changes to individual-specific brain signature with age.Frontiers in aging neuroscience · 2025Article
- Research progress on brain network imaging biomarkers of subjective cognitive decline.Frontiers in neuroscience · 2025Review
- Abnormal neural network connectivity in heart failure with reduced and mild-ranged ejection fraction patients: an independent component and dynamic functional network connectivity analysis.Frontiers in neurology · 2025Article
- The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression.Nature communications · 2024Article
- Cross-cohort replicable resting-state functional connectivity in predicting symptoms and cognition of schizophrenia.Human brain mapping · 2024Article
- Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study.Biological psychiatry · 2024Article
- Searching Reproducible Brain Features using NeuroMark: Templates for Different Age Populations and Imaging Modalities.NeuroImage · 2024Article
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
Abstract
Cognitive decline is amongst one of the most commonly reported complaints during normal aging. Despite evidence that age and cognition are linked with similar neural correlates, no previous studies have directly ascertained how these two constructs overlap in the brain in terms of neuroimaging-based prediction. Based on a long lifespan healthy cohort (CamCAN, aged 19-89 years, n = 567), it is shown that both cognitive function (domains spanning executive function, emotion processing, motor function, and memory) and human age can be reliably predicted from unique patterns of functional connectivity, with models generalizable in two external datasets (n = 533 and n = 453). Results show that cognitive decline and normal aging both manifest decrease within-network connections (especially default mode and ventral attention networks) and increase between-network connections (somatomotor network). Whereas dorsal attention network is an exception, which is highly predictive on cognitive ability but is weakly correlated with aging. Further, the positively weighted connections in predicting fluid intelligence significantly mediate its association with age. Together, these findings offer insights into why normal aging is often associated with cognitive decline in terms of brain network organization, indicating a process of neural dedifferentiation and compensational theory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.