Evidence map›Paper›PMID 35810740›Full record

ArticleUrologia internationalis2023

The Need for Routine Native Nephrectomy in the Workup for Kidney Transplantation in Autosomal Dominant Polycystic Kidney Disease Patients.

Niek F Casteleijn, Paul Geertsema, Iris W Koorevaar, Friso D J Inkelaar, Marnix R Jansen, Steven J Lohuis, Esther Meijer, Robert A Pol, Jan-Stephan Sanders, Peter E van de Streek and 2 more

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In one paragraph

Article in Urologia internationalis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Foam sclerotherapy for symptomatic cysts in ADPKD, ADPLD and solitary cysts.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Observational
  4. Article
  5. Nephrectomy in autosomal dominant polycystic kidney disease: a consensus statement of the ERA Genes & Kidney Working Group.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Niek F CasteleijnDepartment of Urology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Paul GeertsemaDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Iris W KoorevaarDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Friso D J InkelaarDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Marnix R JansenDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Steven J LohuisDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Esther MeijerDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Robert A PolDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jan-Stephan SandersDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Peter E van de StreekDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Anna M LeliveldDepartment of Urology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ron T GansevoortDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is no consensus if nor when a native nephrectomy should be performed in the workup for kidney transplantation in ADPKD patients. In our PKD Expertise Center, a restrictive approach is pursued in which nephrectomy is performed only in patients with severe complaints, i.e., in case of serious volume-related complaints, lack of space for the allograft, recurrent cyst infections, persistent cyst bleedings, or chronic refractory pain. We analyzed in a retrospective cohort study whether this approach is justified.

methodsAll ADPKD patients who received kidney transplantation between January 2000 and January 2019 were reviewed. Patients were subdivided into three groups: no nephrectomy (no-Nx), nephrectomy performed before (pre-Tx), or after kidney transplantation (post-Tx). Simultaneous nephrectomy together with transplantation were not performed in our center.

results391 patients (54 ± 9 years, 55% male) were included. The majority of patients did not undergo a nephrectomy (n = 257, 65.7%). A nephrectomy was performed pre-Tx in 114 patients (29.2%). After Tx, nephrectomy was performed in only 30 patients (7.7%, median 4.4 years post-Tx). Surgery-related complication rates did not differ between both groups (38.3% pre-Tx vs. 27.0% post-Tx, p = 0.2), nor were there any differences in 10-year patient survival (74.4% pre-Tx vs. 80.7% post-Tx vs. 67.6% no-Nx, p = 0.4), as well as in 10-year death-censored graft survival (84.4% pre-Tx vs. 85.5% post-Tx vs. 90.0% no-Nx, p = 0.9).

conclusionsThis study indicates that with a restrictive nephrectomy policy in the workup for kidney transplantation, only a part of ADPKD patients need a native nephrectomy.

Indexed as

CystsKidney TransplantationPolycystic Kidney, Autosomal DominantFemaleHumansMaleReinfectionRetrospective StudiesTreatment OutcomeAutosomal dominant polycystic kidney diseaseNephrectomyPolycystic kidney diseaseTransplantation

Identifiers

PMID35810740
PMCPMC9945191
OpenAlexW4284967542

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.