Evidence map›Paper›PMID 35810394›Full record

ArticleCellular and molecular life sciences : CMLS2022

Increased H3K27 trimethylation contributes to cone survival in a mouse model of cone dystrophy.

Annie L Miller, Paula I Fuller-Carter, Klaudija Masarini, Marijana Samardzija, Kim W Carter, Rabab Rashwan, Xin Ru Lim, Alicia A Brunet, Abha Chopra, Ramesh Ram and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Exploring Histone Modifications in Inherited Retinal Disorders.Advances in experimental medicine and biology · 2025
    Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 5 countries.

Annie L MillerRetinal Genomics and Therapy Group, Lions Eye Institute Ltd, 2 Verdun Street, Nedlands, WA, 6009, Australia.
Paula I Fuller-CarterRetinal Genomics and Therapy Group, Lions Eye Institute Ltd, 2 Verdun Street, Nedlands, WA, 6009, Australia.
Klaudija MasariniInstitute for Ophthalmic Research, Tübingen University, Elfriede-Aulhorn-Straße 7, 72076, Tübingen, Germany.
Marijana SamardzijaLab for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zürich, University of Zürich, Zurich, Switzerland.
Kim W CarterAnalytical Computing Solutions, Willetton, WA, 6155, Australia.
Rabab RashwanRetinal Genomics and Therapy Group, Lions Eye Institute Ltd, 2 Verdun Street, Nedlands, WA, 6009, Australia.
Xin Ru LimRetinal Genomics and Therapy Group, Lions Eye Institute Ltd, 2 Verdun Street, Nedlands, WA, 6009, Australia.
Alicia A BrunetRetinal Genomics and Therapy Group, Lions Eye Institute Ltd, 2 Verdun Street, Nedlands, WA, 6009, Australia.
Abha ChopraInstitute for Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia.
Ramesh RamInstitute for Immunology and Infectious Diseases, Murdoch University, Murdoch, WA, Australia.
Christian GrimmLab for Retinal Cell Biology, Department of Ophthalmology, University Hospital Zürich, University of Zürich, Zurich, Switzerland.
Marius UeffingInstitute for Ophthalmic Research, Tübingen University, Elfriede-Aulhorn-Straße 7, 72076, Tübingen, Germany.
Livia S CarvalhoRetinal Genomics and Therapy Group, Lions Eye Institute Ltd, 2 Verdun Street, Nedlands, WA, 6009, Australia. liviacarvalho@lei.org.au.ORCID http://orcid.org/0000-0002-3909-5778
Dragana TrifunovićInstitute for Ophthalmic Research, Tübingen University, Elfriede-Aulhorn-Straße 7, 72076, Tübingen, Germany. draganatri@yahoo.com.
Lions Eye Institute · AUUniversity of Tübingen · DEMurdoch University · AUUniversity of Zurich · CH

Funding

Deutsche Forschungsgemeinschaft DFG TR 1238/4-1Swiss National Science Foundation 31003A 173008The Lindsay & Heather Payne Medical Research Charitable Foundation IPAP2020/1082
6 · The paper itself

Abstract

Inherited retinal diseases (IRDs) are a heterogeneous group of blinding disorders, which result in dysfunction or death of the light-sensing cone and rod photoreceptors. Despite individual IRDs (Inherited retinal disease) being rare, collectively, they affect up to 1:2000 people worldwide, causing a significant socioeconomic burden, especially when cone-mediated central vision is affected. This study uses the Pde6c

Indexed as

Color Vision DefectsCone DystrophyAnimalsDisease Models, AnimalHistonesHumansMiceRetinal Cone Photoreceptor CellsHistonesAchromatopsiaCone photoreceptorsGSK-J4H3K27me3Inherited retinal diseaseSingle-cell RNA sequencing

Identifiers

PMID35810394
PMCPMC9271452
OpenAlexW4284990520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.