ArticleJournal of biomedical optics2022
Age-related changes in diffuse optical tomography sensitivity profiles from childhood to adulthood.
Article in Journal of biomedical optics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Ecological functional near-infrared spectroscopy in mobile children: using short separation channels to correct for systemic contamination during naturalistic neuroimaging.Neurophotonics · 2024Article
- Special Section Guest Editorial: Introduction to the Special Section Celebrating 30 years of Open Source Monte Carlo Codes in Biomedical Optics.Journal of biomedical optics · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
significanceDiffuse optical tomography (DOT) uses near-infrared light spectroscopy to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of the brain location that generates the hemodynamic signal require accurate descriptions of the DOT sensitivity to the underlying cortex. DOT sensitivity profiles are different in infants compared with adults. However, the descriptions of DOT sensitivity profiles from early childhood to adulthood are lacking despite the continuous head and brain development.
aimWe aim to investigate age-related differences in DOT sensitivity profiles in individuals aged from 2 to 34 years with narrow age ranges of 0.5 or 1 year. APPROACH: We implemented existing photon migration simulation methods and computed source-detector channel DOT sensitivity using age-appropriate, realistic head models.
resultsDOT sensitivity profiles change systematically as a function of source-detector separation distance for all age groups. Children displayed distinctive DOT sensitivity profiles compared to older individuals, and the differences were enhanced at larger separation distances.
conclusionsThe findings have important implications for the design of source-detector placement and image reconstruction. Age-appropriate realistic head models should be used to provide anatomical guidance for standalone DOT data. Using age-inappropriate head models will have more negative impacts on estimation accuracy in younger children.
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