Evidence map›Paper›PMID 35810239›Full record

ReviewMolecular biology reports2022

Introduction of long non-coding RNAs to regulate autophagy-associated therapy resistance in cancer.

Yanyan Wang, Zhaoping Liu, Zhenru Xu, Wenjun Shao, Dingyu Hu, Huiying Zhong, Ji Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanyan WangThe First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Zhaoping LiuInstitute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Zhenru XuDepartment of Clinical Laboratory, The Second Affiliated Hospital, Hainan Medical University, 570216, Haikou, Hainan, China.
Wenjun ShaoThe First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Dingyu HuThe First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China.
Huiying ZhongThe First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China. hy_zhong001@163.com.
Ji ZhangThe First Affiliated Hospital, Department of Rheumatology, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China. jizhang@fsyy.usc.edu.cn.ORCID http://orcid.org/0000-0002-6610-9805

Funding

National Natural Science Foundation of China 81870105National Natural Science Foundation of China 82170138Natural Science Foundation of Hunan Province 2021JJ30022Scientific Research Fund Project of Hunan Provincial Health Commission 20201921
6 · The paper itself

Abstract

Autophagy is a lysosomal degradation pathway that depends on various evolutionarily conserved autophagy-related genes (ATGs). Dysregulation of autophagy plays an important role in the occurrence and development of cancer. Chemotherapy, targeted therapy, radiotherapy, and immunotherapy are important treatment options for cancer, which can significantly improve the survival rate of cancer patients. However, the occurrence of therapy resistance results in therapeutic failure and poor prognosis of cancer. Accumulating studies have found that long non-coding RNAs (lncRNAs) are well known as crucial regulators to control autophagy through regulating ATGs and autophagy-associated signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway, ultimately mediating chemoresistance and radioresistance. Taken together, this review systematically summarizes and elucidates the pivotal role of lncRNAs in cancer chemoresistance and radioresistance via regulating autophagy. Understanding the specific mechanism of which may provide autophagy-related therapeutic targets for cancer in the future.

Indexed as

NeoplasmsRNA, Long NoncodingAutophagyHumansPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, Long NoncodingTOR Serine-Threonine KinasesAutophagyCancer therapy resistanceLong non-coding RNA (lncRNA)

Identifiers

PMID35810239

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.