ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2023
Synaptic plasticity and mental health: methods, challenges and opportunities.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07684911 (Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - Biomarkers), which is not on this map. Cited by 131 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - Biomarkers
Who cites it
131 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Biochemical Effects of Resveratrol Intake on the Neurobehavioral Aspects of Autism Spectrum Disorders: A Systematic Review.Central nervous system agents in medicinal chemistry · 2026Pooled it
- Neurophysiological biomarkers of treatment response in suicidal ideation: a systematic review.Translational psychiatry · 2025Pooled it
- A systematic review and meta-analysis of neuroimaging studies examining synaptic density in individuals with psychotic spectrum disorders.BMC psychiatry · 2024Pooled it
- Repetitive transcranial magnetic stimulation (rTMS) for comorbid major depressive disorder and hoarding disorder: An open label pilot study.Journal of affective disorders · 2026Trial
- Peripheral miRNA profiling identifies therapy-specific biological trajectories in the treatment of cognitive dysfunction in depression: an exploratory mechanistic study.Scientific reports · 2026Trial
- Psilocybin-assisted neurofeedback for the improvement of executive functions: a randomized semi-naturalistic-lab feasibility study.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Trial
- Post-traumatic stress disorder: pathogenesis, epidemiological characteristics, animal models, and potential therapeutic strategies.Military Medical Research · 2026Review
- Comparing transcranial magnetic stimulation and esketamine treatment response trajectories in resistant depression.Journal of affective disorders · 2026Article
- Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility.Neuron · 2026Article
- Controlling Ion Dynamics at Nanoscale for Memristor-Based Neuromorphic Computing.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Computational modeling of prefrontal-amygdala circuits links functional connectivity alterations to circuit-level mechanisms in major depression.Journal of computational neuroscience · 2026Article
- Neuromorphic Devices and Computing for Sensing, Memory, and Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Neuroinflammation and depression: immune-brain interface mechanisms, biomarker stratification, and therapeutic strategies.Translational psychiatry · 2026Review
- A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants.Molecular psychiatry · 2026Article
- Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Review
- Temporal interference stimulation for deep brain neuromodulation in humans.Nature biomedical engineering · 2026Review
- Pursuing the elusive biosignature for suicide: a decennial update.Molecular psychiatry · 2026Review
- Synaptic Plasticity-Intrinsic Excitability and Antidepressant Discovery.Biomedicines · 2026Review
- Unraveling the enigma: Post-translational modifications in psychiatric disorders and their regulatory mechanisms.Journal of translational internal medicine · 2026Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activity-dependent synaptic plasticity is a ubiquitous property of the nervous system that allows neurons to communicate and change their connections as a function of past experiences. Through reweighting of synaptic strengths, the nervous system can remodel itself, giving rise to durable memories that create the biological basis for mental function. In healthy individuals, synaptic plasticity undergoes characteristic developmental and aging trajectories. Dysfunctional plasticity, in turn, underlies a wide spectrum of neuropsychiatric disorders including depression, schizophrenia, addiction, and posttraumatic stress disorder. From a mechanistic standpoint, synaptic plasticity spans the gamut of spatial and temporal scales, from microseconds to the lifespan, from microns to the entire nervous system. With the numbers and strengths of synapses changing on such wide scales, there is an important need to develop measurement techniques with complimentary sensitivities and a growing number of approaches are now being harnessed for this purpose. Through hemodynamic measures, structural and tracer imaging, and noninvasive neuromodulation, it is possible to image structural and functional changes that underlie synaptic plasticity and associated behavioral learning. Here we review the mechanisms of neural plasticity and the historical and future trends in techniques that allow imaging of synaptic changes that accompany psychiatric disorders, highlighting emerging therapeutics and the challenges and opportunities accompanying this burgeoning area of study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.