Evidence map›Paper›PMID 35810168›Full record

ArticleNature communications2022

ADAMTS18

Jeremiah Bernier-Latmani, Cristina Mauri, Rachel Marcone, François Renevey, Stephan Durot, Liqun He, Michael Vanlandewijck, Catherine Maclachlan, Suzel Davanture, Nicola Zamboni and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
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  5. Article
  6. Article
  7. Review
  8. Transport functions of intestinal lymphatic vessels.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Mechanisms and functions of intestinal vascular specialization.The Journal of experimental medicine · 2024
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Jeremiah Bernier-LatmaniDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne and University of Lausanne, Lausanne, Switzerland. jeremiah.bernier-latmani@unil.ch.ORCID 0000-0002-6407-1049
Cristina MauriDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne and University of Lausanne, Lausanne, Switzerland.
Rachel MarconeBioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
François ReneveyDepartment of Immunobiology, University of Lausanne, Lausanne, Switzerland.
Stephan DurotInstitute of Molecular Systems Biology ETH, Zurich, Switzerland.ORCID 0000-0003-2307-7070
Liqun HeDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Michael VanlandewijckDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Catherine MaclachlanBio Electron Microscopy Laboratory, School of Life Sciences, EPFL, Lausanne, Switzerland.
Suzel DavantureDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne and University of Lausanne, Lausanne, Switzerland.
Nicola ZamboniInstitute of Molecular Systems Biology ETH, Zurich, Switzerland.
Graham W KnottBio Electron Microscopy Laboratory, School of Life Sciences, EPFL, Lausanne, Switzerland.ORCID 0000-0002-2956-9052
Sanjiv A LutherDepartment of Immunobiology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-8758-957X
Christer BetsholtzDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Mauro DelorenziDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-7631-3263
Cathrin BriskenSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, Switzerland.ORCID 0000-0002-6857-3230
Tatiana V PetrovaDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne and University of Lausanne, Lausanne, Switzerland. tatiana.petrova@unil.ch.ORCID 0000-0002-0563-6521
Ludwig Cancer Research · CHÉcole Polytechnique Fédérale de Lausanne · CHUppsala University · SEETH Zurich · CHSIB Swiss Institute of Bioinformatics · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The small intestinal villus tip is the first point of contact for lumen-derived substances including nutrients and microbial products. Electron microscopy studies from the early 1970s uncovered unusual spatial organization of small intestinal villus tip blood vessels: their exterior, epithelial-facing side is fenestrated, while the side facing the villus stroma is non-fenestrated, covered by pericytes and harbors endothelial nuclei. Such organization optimizes the absorption process, however the molecular mechanisms maintaining this highly specialized structure remain unclear. Here we report that perivascular LGR5

Indexed as

IntestinesTelocytesDuodenumIntestinal MucosaNutrientsNutrients

Identifiers

PMID35810168
PMCPMC9271081
OpenAlexW4284968470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.