Evidence map›Paper›PMID 35810012›Full record

Trial reportInternational dental journal2022

Periodontal Treatment for Chronic Periodontitis With Rheumatoid Arthritis.

Sivasankari Thilagar, Ramakrishnan Theyagarajan, Maryam H Mugri, Hammam Ahmed Bahammam, Sarah Ahmed Bahammam, Maha A Bahammam, Pradeep Kumar Yadalam, A Thirumal Raj, Shilpa Bhandi, Shankargouda Patil

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International dental journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
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  9. Journal of oral microbiology · 2026
    Review
  10. Article
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  12. Review
  13. Article
  14. Article
  15. Article
  16. Oral Microbiome Dysbiosis and Citrullination in Rheumatoid Arthritis.Advances in experimental medicine and biology · 2025
    Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Sivasankari ThilagarDepartment of Periodontics, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamil Nadu, India.
Ramakrishnan TheyagarajanDepartment of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India.
Maryam H MugriDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Hammam Ahmed BahammamDepartment of Pediatric Dentistry, College of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Sarah Ahmed BahammamDepartment of Pediatric Dentistry and Orthodontics, College of Dentistry, Taibah University, Medina, Saudi Arabia.
Maha A BahammamDepartment of Periodontology, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; Executive Presidency of Academic Affairs, Saudi Commission for Health Specialties, Riyadh, Saudi Arabia.
Pradeep Kumar YadalamDepartment of Periodontics, Saveetha Dental college and Hospitals, Saveetha Institute of Medical, and Technical Sciences, Saveetha University, Chennai, India.
A Thirumal RajDepartment of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India.
Shilpa BhandiCollege of Dental Medicine, Roseman University of health sciences, South Jordan, Utah, USA.
Shankargouda PatilCollege of Dental Medicine, Roseman University of health sciences, South Jordan, Utah, USA. Electronic address: dr.ravipatil@gmail.com.
King Abdulaziz University · SARoseman University of Health Sciences · USJazan University · SAMeenakshi Ammal Dental College and Hospital · INSaveetha University · INSri Venkateswara Medical College and Ruia Hospital · INTaibah University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHistory of rheumatoid arthritis (RA) increases risk of periodontal diseases. A pro-inflammatory condition noted in periodontitis is considered a trigger for RA. Thus, periodontal treatment aimed at attenuating the pro-inflammatory state could aid in potentially reducing the risk of RA.

aimsThe objective of this research was to assess the effect of periodontal therapy on rheumatoid factor, Disease Activity Score-28, anti-citrullinated protein antibody, and C-reactive protein levels in patients with chronic periodontitis (CP) and RA. MATERIALS AND

methodsThe sample consisted of 28 patients with CP and RA. The study was designed to be a double-blind, randomised controlled clinical study. The samples were randomly categorised to either the treatment group (n = 13) or the control group (n = 15). CP status (plaque index, bleeding on probing, probing pocket depth, clinical attachment loss), clinical rheumatologic status (Disease Activity Score), and biochemical status (C-reactive protein, anti-citrullinated protein antibody, and rheumatoid factor) were assessed at baseline and at follow-up at 8 to 12 weeks.

resultsThe treatment group showed a highly statistically significant reduction in bleeding on probing (P < .005), probing pocket depth (P < .001), plaque index (P < .001), and C-reactive protein (P < .001); a gain in the clinical attachment loss (P < .001) and an improvement in Disease Activity Score-28 (P = .001) were observed at reassessment following nonsurgical periodontal treatment as compared to the control group. However, blood serum anti-citrullinated protein antibody (P = .002) and rheumatoid factor levels (P = .351) were found to increase from baseline to 8 to 12 weeks following subgingival scaling and root planing.

conclusionsReduction of inflammation in the periodontium by nonsurgical periodontal therapy did not reduce anti-citrullinated protein antibody and rheumatoid factor levels. However, it has shown improvement in periodontal conditions, and remarkable changes were observed in the clinical Disease Activity Score and C-reactive protein levels of individuals with RA.

Indexed as

Arthritis, RheumatoidChronic PeriodontitisC-Reactive ProteinDental ScalingHumansRheumatoid FactorC-Reactive ProteinRheumatoid FactorACPA proteinsChronic periodontitisC-reactive proteinsNonsurgical periodontal debridementRheumatoid arthritisRheumatoid factor

Identifiers

PMID35810012
PMCPMC9676424
OpenAlexW4284882446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.