Evidence map›Paper›PMID 35809566›Full record

ArticleCell chemical biology2022

Context-dependent regulation of ferroptosis sensitivity.

Leslie Magtanong, Grace D Mueller, Kevin J Williams, Maximilian Billmann, Katherine Chan, David A Armenta, Lauren E Pope, Jason Moffat, Charles Boone, Chad L Myers and 3 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 108 citations in OpenAlex.

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  15. Review
  16. Dissecting Complex Interactions Between Ferroptosis and the Proteasome.bioRxiv : the preprint server for biology · 2026
    Article
  17. Article
  18. Article
  19. MAFLD: a ferroptotic disease.Trends in molecular medicine · 2026
    Review
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Leslie MagtanongDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Grace D MuellerDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Kevin J WilliamsDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA Lipidomics Laboratory, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Maximilian BillmannDepartment of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
Katherine ChanDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
David A ArmentaDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Lauren E PopeDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Jason MoffatDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Charles BooneDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Chad L MyersDepartment of Computer Science and Engineering, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA; Program in Biomedical Informatics and Computational Biology, University of Minnesota-Twin Cities, 200 Union Street, Minneapolis, MN 55455, USA.
James A OlzmannDepartments of Molecular and Cell Biology and Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Steven J BensingerDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA Lipidomics Laboratory, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Scott J DixonDepartment of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address: sjdixon@stanford.edu.
Stanford University · USUniversity of Toronto · CAUniversity of California, Los Angeles · USUniversity of Minnesota · USChan Zuckerberg Initiative (United States) · USStanford Medicine · US

Funding

Understanding the Influence of Lipid Homeostasis on T cell FunctionP01HL146358 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI YOUNG, STEPHEN G. · 2019 to 2023
$11.7M
Mapping the reference genetic network of a eukaryotic cellR01HG005853 · NHGRI · UNIVERSITY OF TORONTO · PI ANDREWS, BRENDA JEAN, BOONE, CHARLES · 2010 to 2025
$7.6M
Characterizing the Regulation of FerroptosisR01GM122923 · NIGMS · STANFORD UNIVERSITY · PI Scott Dixon · 2017 to 2026
$3.4M
Molecular Mechanisms of Lipid Droplet BiogenesisR01GM112948 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI OLZMANN, JAMES A · 2015 to 2024
$3.1M
Methods for large-scale analysis of chemical-genetic interactionsR01HG005084 · NHGRI · UNIVERSITY OF MINNESOTA · PI MYERS, CHAD L · 2010 to 2022
$2.9M
Investigating the impact of a fatty acid-cRel inflammatory circuit in atherosclerosisR01HL157710 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BENSINGER, STEVEN J · 2021 to 2024
$2.3M
NHGRI NIH HHS R01 HG005084NHGRI NIH HHS R01 HG005853NHLBI NIH HHS P01 HL146358NHLBI NIH HHS R01 HL157710NIGMS NIH HHS R01 GM112948NIGMS NIH HHS R01 GM122923
6 · The paper itself

Abstract

Ferroptosis is an important mediator of pathophysiological cell death and an emerging target for cancer therapy. Whether ferroptosis sensitivity is governed by a single regulatory mechanism is unclear. Here, based on the integration of 24 published chemical genetic screens combined with targeted follow-up experimentation, we find that the genetic regulation of ferroptosis sensitivity is highly variable and context-dependent. For example, the lipid metabolic gene acyl-coenzyme A (CoA) synthetase long chain family member 4 (ACSL4) appears far more essential for ferroptosis triggered by direct inhibition of the lipid hydroperoxidase glutathione peroxidase 4 (GPX4) than by cystine deprivation. Despite this, distinct pro-ferroptotic stimuli converge upon a common lethal effector mechanism: accumulation of lipid peroxides at the plasma membrane. These results indicate that distinct genetic mechanisms regulate ferroptosis sensitivity, with implications for the initiation and analysis of this process in vivo.

Indexed as

FerroptosisCell Line, TumorCoenzyme ACoenzyme A LigasesCystineLipid PeroxidesPhospholipid Hydroperoxide Glutathione PeroxidaseCoenzyme ACoenzyme A LigasesCystineLipid PeroxidesPhospholipid Hydroperoxide Glutathione PeroxidaseACSL4cancerether lipidferroptosisironPUFAROS

Identifiers

PMID35809566
PMCPMC9481678
OpenAlexW4284963783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.