ArticleJournal of clinical hypertension (Greenwich, Conn.)2022
Relationship between serum uric acid and hypertension in patients with primary Sjögren's syndrome: A retrospective cohort study.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Association between primary Sjögren's disease and temporomandibular disorder in Taiwan: a 15-year nationwide cohort, with an exploratory analysis of hydroxychloroquine.BMC oral health · 2026Article
- Hypertension, Dyslipidemia, and Adhesive Capsulitis: A Bidirectional Two-Sample Mendelian Randomization Study of the European Population.Genetics research · 2026Article
- Sjogren's Disease and Elevated Cardiovascular Risk: Mechanisms and Treatment.Journal of cardiovascular development and disease · 2025Review
- Breastfeeding duration and the risk of systemic juvenile idiopathic arthritis: a cross-sectional study.Frontiers in nutrition · 2025Article
- Risk factors for cardiovascular disease in primary Sjögren's syndrome (pSS): a 20-year follow-up study.Clinical rheumatology · 2023Article
- Article
- Relationship between serum uric acid and hypertension in patients with primary Sjögren's syndrome: A retrospective cohort study.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Primary Sjögren's syndrome (pSS) patients with hypertension (pSS-HT) have a significantly increased risk of cardio-cerebrovascular events. Serum uric acid (SUA), a potential inflammatory substance, is considered to be closely related to hypertension in the general population. Our aim is to assess the association between SUA and pSS-HT. This is a retrospective cohort study. The diagnosis of pSS is based on the American European Consensus Classification criteria. Primary outcome was incident hypertension in pSS patients. Cox regression model was used to estimate the hazard ratios (HR) and 95% CI of SUA in pSS-HT. The authors also plotted Kaplan-Meier plots to assess the cumulative risk of first hypertension in patients with hyperuricemia and normal uric acid. In addition, the dose-response curve was also used to discuss the relationship between SUA and pSS-HT. Finally, three hundred and fifty-one pSS patients were enrolled from May 2011 to May 2020, of which 166 cases developed hypertension within a mean follow-up of 3.91 years. Univariate Cox regression demonstrated that SUA was associated with the onset of hypertension in pSS (HR: 1.005 95%Cl: 1.002-1.009). After adjusting for the potential risk factors, the relationship remained unchanged (HR: 1.003, 95%Cl: 1.001-1.005). Kaplan-Meier survival analysis showed a statistically significant difference of hypertension risk between hyperuricemia patients and normal uric acid patients (P = .026). There was also a significant dose-effect relationship between SUA and hypertension in pSS in dose-response model. In this study, the authors find that SUA may be closely associated with the development of hypertension in pSS, which is also confirmed by our dose-response model. Therefore, SUA could be considered in the management of pSS-HT.
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