Evidence map›Paper›PMID 35809154›Full record

ReviewMolecular neurobiology2022

Muscone Can Improve Spinal Cord Injury by Activating the Angiogenin/Plexin-B2 Axis.

Yu Zhou, Shitian Guo, Benson O A Botchway, Yong Zhang, Tian Jin, Xuehong Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yu Zhou *Department of Histology and Embryology, School of Medicine, Medical College, Shaoxing University, Zhejiang Province, Shaoxing, 312000, China.
Shitian Guo *School of Clinical Medicine, Hangzhou Normal University, Hangzhou, China.
Benson O A Botchway *Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China.
Yong Zhang *Department of Histology and Embryology, School of Medicine, Medical College, Shaoxing University, Zhejiang Province, Shaoxing, 312000, China.
Tian JinDepartment of Histology and Embryology, School of Medicine, Medical College, Shaoxing University, Zhejiang Province, Shaoxing, 312000, China.
Xuehong LiuDepartment of Histology and Embryology, School of Medicine, Medical College, Shaoxing University, Zhejiang Province, Shaoxing, 312000, China. liuxueh6588@126.com.ORCID http://orcid.org/0000-0003-4325-6762
Shaoxing University · CNHangzhou Normal University · CNZhejiang University · CN

Funding

Natural Science Foundation of Zhejiang Province LY19H170001
6 · The paper itself

Abstract

Spinal cord injury (SCI) is a devastating neurological disorder that usually damages sensorimotor and autonomic functions. Signaling pathways can play a key role in the repair process of SCI. The plexin-B2 acts as a receptor for angiogenin and mediates ribosomal RNA transcription, influencing cell survival and proliferation. Protein kinase B serine/threonine kinase interacts with angiogenin to form a positive feedback effect. Brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor can induce angiogenin nuclear translocation. Moreover, the BDNF can promote the secretion of angiogenin. Interestingly, all of them can activate the angiogenin/plexin-B2 axis. Muscone has anti-inflammatory and proliferative features as it can inhibit nuclear transcription factor kappa-B (NF-κB) and activate the angiogenin/plexin-B2 axis, thus being significant agent in the SCI repair process. Herein, we review the potential mechanism of angiogenin/plexin-B2 axis activation and the role of muscone in SCI treatment. Muscone may attenuate inflammatory responses and promote neuronal regeneration after SCI.

Indexed as

Brain-Derived Neurotrophic FactorSpinal Cord InjuriesCell Adhesion MoleculesCycloparaffinsHumansNerve Tissue ProteinsNF-kappa BRibonuclease, PancreaticSpinal CordVascular Endothelial Growth Factor AangiogeninBrain-Derived Neurotrophic FactorCell Adhesion MoleculesCycloparaffinsmusconeNerve Tissue ProteinsNF-kappa BplexinPLXNB2 protein, humanRibonuclease, PancreaticVascular Endothelial Growth Factor AAngiogenin/plexin-B2 axisAnti-inflammationCell proliferationMusconeSpinal cord injury

Identifiers

PMID35809154
OpenAlexW4284970785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.