Trial reportEuropean journal of applied physiology2022
Exercise-induced hypoalgesia (EIH) in response to different exercise intensities.
Trial report in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Autonomic responses to aerobic and resistance exercise in patients with chronic musculoskeletal pain: A systematic review.PloS one · 2023Pooled it
- Acute effects of aerobic versus combined aerobic and cervical-upper extremity resistance exercise on pressure pain threshold, pain perception, and fatigue in workers exposed to high ergonomic risk with chronic non-specific neck pain: a randomized controlled trial.BMC musculoskeletal disorders · 2026Trial
- Acute Clinical Effects of Dual-Task Resistance Exercise on Muscle Endurance and Pressure Sensitivity in Patients With Carpal Tunnel Syndrome After Surgery.Musculoskeletal care · 2026Trial
- Cryo-Induced Hypoalgesia: The Effects of an Acute Cryochamber Exposure on Pain Perception-A Randomised Controlled Cross-Over Trial.European journal of pain (London, England) · 2025Trial
- The effect of stretching intensity on pain sensitivity: A randomized crossover study on healthy adults.European journal of pain (London, England) · 2025Trial
- Ten Minutes of Core Stabilisation Exercise Result in Local Exercise-Induced Hypoalgesia in Patients With Chronic Unspecific Low Back Pain.European journal of pain (London, England) · 2025Trial
- Resting-state cortical activity, biomarkers and functional performance identify distinct biopsychosocial phenotypes in young adults with chronic postsurgical pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Conditioned pain modulation, cortical imbalance, and arthrogenic muscle inhibition: an integrative model with implications for exercise in chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Sex Is Not an Independent Predictor of Exercise-Induced Pain After Adjustment for Performance and Pain Sensitivity.Pain research & management · 2025Article
- Relationship Between Frequency of Physical Activity, Functional Mobility, and Self-Perceived Health in People with Different Levels of Pain: A Cross-Sectional Study.Journal of functional morphology and kinesiology · 2024Article
- Exercise induced hypoalgesia after a high intensity functional training: a randomized controlled crossover study.BMC sports science, medicine & rehabilitation · 2024Article
- The Role of Physical Exercise in Chronic Musculoskeletal Pain: Best Medicine-A Narrative Review.Healthcare (Basel, Switzerland) · 2024Review
- Exercise-Induced Hypoalgesia in Patients with Chronic Whiplash-Associated Disorders: Differences between Subgroups Based on the Central Sensitization Inventory.Journal of clinical medicine · 2024Article
- Examining Changes in Pain Sensitivity Following 8 Minutes of Cycling at Varying Exercise Intensities.International journal of exercise science · 2024Article
- Article
- Exercise-induced hypoalgesia in healthy males is best explained by mechanisms selectively affecting deep-tissue pain sensitivity within exercising body parts.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAcute physical activity leads to exercise-induced hypoalgesia (EIH). The aim of this study was to investigate the effects of four different exercise intensities on EIH.
methods25 male (age: 24.7 ± 3.0) subjects underwent four different exercise sessions on a bicycle ergometer for 30 min each at 60, 80, 100, and 110% of the individual anaerobic threshold on separate days in a randomized crossover design. Before, as well as 5- and 45-min post-exercise, pain sensitivity was measured employing pain pressure thresholds (PPT) at the elbow, knee, and ankle joints as well as the sternum and forehead. Besides, conditioned pain modulation (CPM) was conducted using thermal test- and conditioned stimuli before, 5-, and 45-min post-exercise.
resultsA main time effect was observed regarding PPT at all landmarks except for the forehead with higher values observed 5 and 45 min post-exercise compared to the pre-values. Yet, no interaction effects occurred. CPM did not change in response to any of the intensities used.
conclusionEIH occurs 5 and 45 min after exercise regardless of the intensity used at the joints and sternum which might be explained by local pain-inhibiting pathways and probably to a limited degree by central mechanisms, as no hypoalgesia was observed at the forehead and no changes in CPM occurred.
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Registered trials
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