ReviewJournal of sleep research2022
Restless legs syndrome: Over 50 years of European contribution.
Review in Journal of sleep research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Smoking and risk of restless leg syndrome: a systematic review, meta-analysis, and Mendelian randomisation.Journal of global health · 2026Pooled it
- Comparative Peripheral Blood Transcriptomic Profiles in Parkinson's Disease and Restless Legs Syndrome: An Exploratory Between-Cohort Analysis.International journal of molecular sciences · 2026Article
- Association between homocysteine and periodic limb movement during sleep in samples from the São Paulo epidemiological sleep study (EPISONO): Homocysteine and PLMS in the EPISONO study.Sleep and biological rhythms · 2026Article
- Serum Biomarkers in Restless Legs Syndrome: Beyond the Classical Iron Paradigm-A Scoping Review.International journal of molecular sciences · 2026Article
- Primary healthcare nurses' experiences of symptoms and treatment needs of patients with RLS-associated symptoms at telephone nursing - an abductive analysis based on the Four Habits communication model.International journal of qualitative studies on health and well-being · 2025Article
- Experiences of sleep problems, subsequent daytime consequences, and self-care activities used to improve sleep among patients with restless legs syndrome: a qualitative content analysis.Journal of research in nursing : JRN · 2025Article
- Prerequisites for self-care actions in individuals with restless legs syndrome-A deductive qualitative analysis based on the COM-B model.Journal of health psychology · 2025Article
- TLR1-Regulated Ferroptosis Gene Decreases the Occurrence of Restless Legs Syndrome.Brain and behavior · 2025Article
- Sleep and Stroke-An Overlooked Bidirectional Influence: Why Should Sleep and Vascular Neurologists Work Closer?Journal of clinical medicine · 2025Article
- Self-care behaviours in patients with restless legs syndrome (RLS): development and psychometric testing of the RLS-Self-care Behaviour questionnaire.Journal of sleep research · 2025Article
- Associations Between Lifetime Histories of Iron Deficiency, Anxiety, Depression and Multiple Pain Conditions: An Observational Study Using a Large-Scale National Database.Journal of pain research · 2025Article
- Experiences of facilitators and barriers for fulfilment of human needs when living with restless legs syndrome: a qualitative study.International journal of qualitative studies on health and well-being · 2024Article
- Unfolding the role of exercise in the management of sleep disorders.European journal of applied physiology · 2024Review
- The ethos brief index-validation of a brief questionnaire to evaluate wellness based on a holistic perspective in patients with restless legs syndrome.Sleep & breathing = Schlaf & Atmung · 2024Article
- Restless leg syndrome as a complication of primary hyperparathyroidism: insights from a retrospective study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Unveiling the pathophysiology of restless legs syndrome through transcriptome analysis.iScience · 2024Article
- Alexithymia, Anger, Sensitivity to Mild Bodily Sensations and Personality Characteristics of Restless Legs Syndrome Patients: A Case-control Study.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2024Article
- The psychometric properties of the Pearlin Mastery Scale in persons living with restless legs syndrome.PloS one · 2024Article
- Restless Legs Syndrome in Parkinson's Disease.Journal of personalized medicine · 2023Article
- Commentary: Increased Risk of Cardiovascular Disease in Restless Legs Syndrome Patients: A Call to Action.Alpha psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Restless legs syndrome (RLS) is a sensorimotor neurological disorder characterised by an urge to move the limbs with a circadian pattern (occurring in the evening/at night), more prominent at rest, and relieved with movements. RLS is one of the most prevalent sleep disorders, occurring in 5%-10% of the European population. Thomas Willis first described RLS clinical cases already in the 17th century, and Karl-Axel Ekbom described the disease as a modern clinical entity in the 20th century. Despite variable severity, RLS can markedly affect sleep (partly through the presence of periodic leg movements) and quality of life, with a relevant socio-economic impact. Thus, its recognition and treatment are essential. However, screening methods present limitations and should be improved. Moreover, available RLS treatment options albeit providing sustained relief to many patients are limited in number. Additionally, the development of augmentation with dopamine agonists represents a major treatment problem. A better understanding of RLS pathomechanisms can bring to light novel treatment possibilities. With emerging new avenues of research in pharmacology, imaging, genetics, and animal models of RLS, this is an interesting and constantly growing field of research. This review will update the reader on the current state of RLS clinical practice and research, with a special focus on the contribution of European researchers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.