Evidence map›Paper›PMID 35808908›Full record

SynthesisPrenatal diagnosis2022

Gestational age at birth and outcome in monochorionic twins with different types of selective fetal growth restriction: A systematic literature review.

Salma El Emrani, Sophie G Groene, E Joanne Verweij, Femke Slaghekke, Asma Khalil, Jeanine M M van Klink, Eleonor Tiblad, Liesbeth Lewi, Enrico Lopriore

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Prenatal diagnosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Prognostic performance of umbilical artery Doppler-based classification in monochorionic pregnancies complicated by selective fetal growth restriction.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Management of monochorionic diamniotic twin gestation affected by Type-II selective fetal growth restriction: cost-effectiveness analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Salma El EmraniDepartment of Pediatrics, Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
Sophie G GroeneDepartment of Pediatrics, Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-8832-045X
E Joanne VerweijDepartment of Obstetrics, Fetal Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-9343-9957
Femke SlaghekkeDepartment of Obstetrics, Fetal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Asma KhalilDepartment of Obstetrics, Fetal Medicine Unit, St George's Hospital, University of London, London, UK.
Jeanine M M van KlinkDepartment of Pediatrics, Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
Eleonor TibladCenter for Fetal Medicine, Pregnancy Care and Delivery, Women's Health, Karolinska University Hospital, Stockholm, Sweden.
Liesbeth LewiDepartment of Obstetrics, Fetal Medicine, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-9884-5778
Enrico LoprioreDepartment of Pediatrics, Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, The Netherlands.
Leiden University Medical Center · NLKarolinska University Hospital · SEKU Leuven · BEUniversity of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review aims to assess the gestational age at birth and perinatal outcome [intrauterine demise (IUD), neonatal mortality and severe cerebral injury] in monochorionic twins with selective fetal growth restriction (sFGR), according to Gratacós classification based on umbilical artery Doppler flow patterns in the smaller twin. Seventeen articles were included. Gestational age at birth varied from 33.0 to 36.0 weeks in type I, 27.6-32.4 weeks in type II, and 28.3-33.8 weeks in type III. IUD rate differed from 0%-4% in type I to 0%-40% in type II and 0%-23% in type III. Neonatal mortality rate was between 0%-10% in type I, 0%-38% in type II, and 0%-17% in type III. Cerebral injury was present in 0%-2% of type I, 2%-30% of type II and 0%-33% of type III cases. The timing of delivery in sFGR varied substantially among studies, particularly in type II and III. The quality of evidence was moderate due to heterogenous study populations with varying definitions of sFGR and perinatal outcome parameters, as well as a lack of consensus on the use of the Gratacós classification, leading to substantial incomparability. Our review identifies the urgent need for uniform antenatal diagnostic criteria and definitions of outcome parameters.

Indexed as

Fetal Growth RetardationTwins, MonozygoticDiseases in TwinsFemaleGestational AgeHumansInfant, NewbornPregnancyPregnancy, TwinRetrospective StudiesUltrasonography, PrenatalUmbilical Arteries

Identifiers

PMID35808908
PMCPMC9543733
OpenAlexW4284992266

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.