ArticleJournal of clinical laboratory analysis2022
Serum uric acid to creatinine ratio is associated with higher prevalence of NAFLD detected by FibroScan in the United States.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- The association of serum uric acid level and the uric acid to creatinine ratio with non alcoholic fatty liver disease in children with obesity.Scientific reports · 2025Article
- Triglyceride-glucose-waist circumference index: A powerful tool for metabolic dysfunction-associated steatotic liver disease.World journal of hepatology · 2025Review
- Serum Uric Acid-to-Serum Creatinine Ratio, Thyroid Function, and Gestational Diabetes Mellitus Risk during Early Pregnancy among Chinese Women.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association of serum uric acid with hepatic steatosis detected by controlled attenuation parameter in the United States population.Lipids in health and disease · 2023Article
- Serum uric acid to creatinine ratio is a useful predictor of all-cause mortality among hypertensive patients.Clinical hypertension · 2023Article
- Article
- Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease in American adults: a population-based analysis.Frontiers in medicine · 2023Article
- Serum uric acid to creatinine ratio is associated with higher prevalence of NAFLD detected by FibroScan in the United States.Journal of clinical laboratory analysis · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between the serum uric acid (sUA) to creatinine ratio (sUA/Cr) and non-alcoholic fatty liver disease (NAFLD) has not been sufficiently clarified. In this study, we investigated the relationship between sUA/Cr and NAFLD among participants in the United States.
methodsWe performed a cross-sectional study based on data from the National Health and Nutrition examination Survey (NHANES) 2017-2018. A measured controlled attenuation parameter (CAP) value of ≥274 dB/m detected by Fibroscan was used to identify hepatic steatosis. SUA/Cr was calculated as sUA divided by serum creatinine. Multivariate logistic regression analysis was used to estimate the association between sUA/Cr and NAFLD. The adjusted odds ratio (OR) of sUA/Cr for NAFLD was estimated, and subgroup analysis stratified by sex was also conducted. The nonlinear relationship between sUA/Cr and NAFLD was further described using smooth curve fittings and threshold-effect analysis.
resultsWe found that sUA/Cr was positively correlated with NAFLD status after fully adjustment for confounding factors. In subgroup analysis stratified by sex, the positive interaction between sUA/Cr and NAFLD status only existed in women but not in men. Moreover, the nonlinear association between sUA/Cr and NAFLD status was an inverted U-shaped curve with an inflection point at 9.7 among men.
conclusionsOur study identified that sUA/Cr was positively associated with the risk of NAFLD among individuals in the United States. Moreover, the correlation between sUA/Cr and NAFLD differed according to sex.
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