Evidence map›Paper›PMID 35808588›Full record

ArticlePolymers2022

High-Resolution 3D Printing Fabrication of a Microfluidic Platform for Blood Plasma Separation.

Sandra Garcia-Rey, Jacob B Nielsen, Gregory P Nordin, Adam T Woolley, Lourdes Basabe-Desmonts, Fernando Benito-Lopez

Abstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Extracellular Vesicle Preparation and Analysis: A State-of-the-Art Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  5. Review
  6. Article
  7. Microfluidic Organ-on-A-chip: A Guide to Biomaterial Choice and Fabrication.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandra Garcia-ReyMicrofluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip (AMMa-LOAC) Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.
Jacob B NielsenDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA.
Gregory P NordinDepartment of Electrical and Computer Engineering, Brigham Young University, Provo, UT 84602, USA.ORCID 0000-0001-7241-5764
Adam T WoolleyDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA.ORCID 0000-0002-4699-8094
Lourdes Basabe-DesmontsMicrofluidics Cluster UPV/EHU, BIOMICs Microfluidics Group, Lascaray Research Center, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain.
Fernando Benito-LopezMicrofluidics Cluster UPV/EHU, Analytical Microsystems & Materials for Lab-on-a-Chip (AMMa-LOAC) Group, Analytical Chemistry Department, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.ORCID 0000-0003-0699-5507

Funding

High Density 3D Printed Microfluidics With Open Source Resins for Biomedical ApplicationsR15GM123405 · NIGMS · BRIGHAM YOUNG UNIVERSITY · PI NORDIN, GREGORY P. · 2017 to 2023
$1.3M
3D-Printed Integrated Microfluidic Devices for Preterm Birth Biomarker AnalysisR01EB027096 · NIBIB · BRIGHAM YOUNG UNIVERSITY · PI WOOLLEY, ADAM THOMAS · 2018 to 2021
$1.1M
Basque Government Grant IT1271-19European Union's Horizon 2020 research and innovation program 766007European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant 778001 (DNASurf)Ministerio de Ciencia y Educación de España PID2020-120313GB-I00 / AIE / 10.13039/501100011033NIBIB NIH HHS R01 EB027096NIGMS NIH HHS R15 GM123405US National Institutes of Health R01 EB027096 and GM123405-A1
6 · The paper itself

Abstract

Additive manufacturing technology is an emerging method for rapid prototyping, which enables the creation of complex geometries by one-step fabrication processes through a layer-by-layer approach. The simplified fabrication achieved with this methodology opens the way towards a more efficient industrial production, with applications in a great number of fields such as biomedical devices. In biomedicine, blood is the gold-standard biofluid for clinical analysis. However, blood cells generate analytical interferences in many test procedures; hence, it is important to separate plasma from blood cells before analytical testing of blood samples. In this research, a custom-made resin formulation combined with a high-resolution 3D printing methodology were used to achieve a methodology for the fast prototype optimization of an operative plasma separation modular device. Through an iterative process, 17 different prototypes were designed and fabricated with printing times ranging from 5 to 12 min. The final device was evaluated through colorimetric analysis, validating this fabrication approach for the qualitative assessment of plasma separation from whole blood. The 3D printing method used here demonstrates the great contribution that this microfluidic technology will bring to the plasma separation biomedical devices market.

Indexed as

3D printingfabricationhigh resolutionplasma separationstereolithographywhole blood

Identifiers

PMID35808588
PMCPMC9269563

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.