SynthesisNutrients2022
Protein Intake and Frailty in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies.
Synthesis in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between frailty and hypoproteinaemia in older patients: meta-analysis and systematic review.BMC geriatrics · 2024Pooled it
- Estimating protein intake in sarcopenic older adults: combining food diaries and weighed powders versus 24-hour urine collections.The journal of nutrition, health & aging · 2025Trial
- Dietary Food-Group Diversity Is Associated with Lower Frailty Severity in Older Adults Undergoing Geriatric Outpatient Assessment.Foods (Basel, Switzerland) · 2026Article
- Network Analysis of Food Intake Patterns and Frailty Dimensions in Chinese Older Adults: A National Cross-Sectional Study.Nutrients · 2026Article
- "At Least the Second Plate": rethinking nutritional care in the geriatric unit.The journal of nutrition, health & aging · 2026Review
- Associations between frailty severity and dietary quality and food security among older Korean adults: a cross-sectional study.BMC geriatrics · 2026Article
- Association between nutrient intake and frailty status in Korean older adults: a cross-sectional study using the 9th (2022-2023) Korea National Health and Nutrition Examination Survey.Korean journal of community nutrition · 2026Article
- Protein intake and its interaction with dietary patterns on clinical outcomes among older adults.npj aging · 2026Article
- Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study.BMC medicine · 2025Article
- Impact of energy intake on the association between protein intake and the prevalence of frailty in older Korean adults: The Korea National Health and Nutrition Examination Survey, 2014-2018.The journal of nutrition, health & aging · 2025Article
- Identification of nutrition factors in the metabolic syndrome and its progression over time in older adults: analysis of the TUDA cohort.Diabetology & metabolic syndrome · 2024Article
- The Association between Dietary Protein Diversity and Protein Patterns with Frailty in Older Chinese Adults: A Population-Based Cohort Study.The journal of nutrition, health & aging · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe present systematic review and meta-analysis investigated the cross-sectional and longitudinal associations between protein intake and frailty in older adults.
methodsWe conducted a systematic review and meta-analysis of cross-sectional and longitudinal studies that investigated the association between protein intake and frailty in older adults. Cross-sectional, case-control, and longitudinal cohort studies that investigated the association between protein intake and frailty as a primary or secondary outcome in people aged 60+ years were included. Studies published in languages other than English, Italian, Portuguese, or Spanish were excluded. Studies were retrieved on 31 January 2022.
resultsTwelve cross-sectional and five longitudinal studies that investigated 46,469 community-dwelling older adults were included. The meta-analysis indicated that absolute, bodyweight-adjusted, and percentage of protein relative to total energy consumption were not cross-sectionally associated with frailty. However, frail older adults consumed significantly less animal-derived protein than robust people. Finally, high protein consumption was associated with a significantly lower risk of frailty.
conclusionsOur pooled analysis indicates that protein intake, whether absolute, adjusted, or relative to total energy intake, is not significantly associated with frailty in older adults. However, we observed that frail older adults consumed significantly less animal protein than their robust counterparts.
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Registered trials
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