ArticleNutrients2022
The Cow's Milk Related Symptom Score: The 2022 Update.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Guidelines on diagnosis and management of gastroesophageal reflux disease in infants, children and adolescents: a joint consensus from Italian pediatric societies (SIP and SIGENP) -Part II: management.Italian journal of pediatrics · 2026Guideline
- Cow's Milk-related Symptom Score for cow's milk allergy assessment: a meta-analysis for test accuracy.Pediatric research · 2023Pooled it
- Percentiles for crying, regurgitation, stool consistency, and CoMiSSPediatric research · 2026Article
- A Qualitative Study Evaluating the Parent-Specific Cow's Milk-Related Symptom Score (Pre-CoMiSS™).Nutrients · 2026Article
- Observational
- Amino acid-based formula with synbiotics for cow's milk protein allergy: a real-world study of symptom evolution and quality-of-life outcomes.Frontiers in pediatrics · 2026Article
- Evaluating the effectiveness of elimination diet in infants with CMP-induced allergic proctocolitis using CoMiSS.Pediatric research · 2026Article
- Infantile Colic: When to Suspect Cow's Milk Allergy.Nutrients · 2025Review
- Article
- Prevalence and possible causes of crying and mild gastrointestinal and skin symptoms in infants reported by healthcare professionals - worldwide data.European journal of pediatrics · 2025Article
- Evaluating the Need for Pre-CoMiSS™, a Parent-Specific Cow's Milk-Related Symptom Score: A Qualitative Study.Nutrients · 2025Article
- Difference in Cow's Milk-Related Symptom Score (CoMiSSPediatric gastroenterology, hepatology & nutrition · 2025Article
- Goat Milk-Based Infant Formula and the Prevalence of Gastrointestinal Symptoms in Infants: A Real-World-Evidence Study From Brazil, Mexico, Russia, and the Netherlands.Health science reports · 2025Article
- Article
- Serum eosinophil-derived neurotoxin: a new promising biomarker for cow's milk allergy diagnosis.Pediatric research · 2024Article
- The evolution of Cow's Milk-related Symptom Score (CoMiSS™) in presumed healthy infants.European journal of pediatrics · 2024Article
- The Cow's Milk-Related Symptom Score (CoMiSSNutrients · 2024Article
- Cow's Milk-related Symptom Score (CoMiSS) values in presumed healthy European infants aged 6-12 months: a cross-sectional study.European journal of pediatrics · 2024Article
- Impacts of people at-risk of either cow milk allergies or lactose intolerance on their daily calcium intake and bone mineral density.Frontiers in nutrition · 2024Article
- The Remaining Challenge to Diagnose and Manage Cow's Milk Allergy: An Opinion Paper to Daily Clinical Practice.Nutrients · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 10 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CoMiSS® was developed 7 years ago to increase the awareness of health care professionals towards the possibility that symptoms presented by infants could be related to cow’s milk. While CoMiSS was conceived mostly on theoretical concepts, data is now available from 25 clinical trials. Based on this extensive research using the tool since 2015, we aim to propose an updated CoMiSS. The evidence was reviewed, debated and discussed by 10 experts, of whom seven were part of the original group. The panel concluded that the cut-off previously proposed to indicate the likelihood that symptoms may be cow’s milk related should be lowered from ≥12 to ≥10. Data in healthy infants > 6 months are missing. Since the Brussels Infant and Toddlers Stool Scale (BITSS) was recently developed for non-toilet trained children, the Bristol Stool Scale was changed to the BITSS without changing the impact of stool characteristics on CoMiSS. Overall, CoMiSS raises awareness that symptoms might be cow’s milk related. New studies are needed to determine if the change in cut-off and other small adaptions improve its sensitivity and specificity. Data for CoMiSS is still needed in presumed healthy infants between 6 and 12 months old. There may also be regional differences in CoMiSS, in healthy infants as well as in those with cow’s milk allergy. Finally, we emphasize that CoMiSS is an awareness tool and not a diagnostic test.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.