Trial reportNutrients2022
A Four-Probiotic Regime to Reduce Surgical Site Infections in Multi-Trauma Patients.
Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- The role of nutritional supplementation in preventing postoperative complications: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Guidelines for Enhanced Recovery After Trauma and Intensive Care (ERATIC): Enhanced Recovery After Surgery (ERAS) and International Association for Trauma Surgery and Intensive Care (IATSIC) Society Recommendations: Paper 2: Postoperative and Intensive Care Recommendations.World journal of surgery · 2025Guideline
- Strategies to Maximize the Benefits of Evidence-Based Enteral Nutrition: A Narrative Review.Nutrients · 2025Pooled it
- The Effects of Probiotics, Prebiotics and Synbiotics on Wound Infection: A Systematic Review.Current pharmaceutical biotechnology · 2025Pooled it
- Probiotics in the ICU: a scoping review of evidence for infection prevention.Journal of translational medicine · 2026Article
- Article
- Probiotics: A Little Help for Enteral Nutritional Therapy in Critically Ill Adults.International journal of molecular sciences · 2025Review
- Probiotic treatment in an intensive care unit: a narrative review.Journal of intensive care · 2025Review
- Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics.Microorganisms · 2025Review
- The Japanese Critical Care Nutrition Guideline 2024.Journal of intensive care · 2025Review
- Probiotics in Traumatic Brain Injury: New Insights into Mechanisms and Future Perspectives.Journal of clinical medicine · 2024Review
- Overview of the Efficacy of Using Probiotics for Neurosurgical and Potential Neurosurgical Patients.Microorganisms · 2024Review
- The Effect of Probiotics on the Prognostication of the Neutrophil-to-Lymphocyte Ratio in Severe Multi-Trauma Patients.Journal of personalized medicine · 2024Article
- The Role of the Gut Microbiome in the Development of Acute Pancreatitis.International journal of molecular sciences · 2024Review
- Microbiota modifications in prehabilitation - the next step towards comprehensive preparation for surgery. The scoping review.Przeglad gastroenterologiczny · 2024Review
- Looking for the Ideal Probiotic Healing Regime.Nutrients · 2023Review
- The Role of Probiotics in Inflammation Associated with Major Surgery: A Narrative Review.Nutrients · 2023Review
- The Probiotic Strains Bifidοbacterium lactis, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Saccharomyces boulardii Regulate Wound Healing and Chemokine Responses in Human Intestinal Subepithelial MyofibroblastsPharmaceuticals (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Investigations that focused on the protective role of probiotics against Surgical Site Infections (SSI) in multiple-trauma (MT) patients are generally few, probably due to the complexity of the concept of trauma. We aimed to assess the efficacy of a four-probiotic regime to reduce the incidence of SSI in MT patients, with a brain injury included. MT patients, being intubated and expected to require mechanical ventilation for >10 days, were randomly allocated into placebo (n = 50) or probiotic treatment (n = 53) comprising Lactobacillus acidophilus LA-5 (1.75 × 109 cfu), Lactiplantibacillus plantarum UBLP-40 (0.5 × 109 cfu), Bifidobacterium animalis subsp. lactis BB-12 (1.75 × 109 cfu), and Saccharomycesboulardii Unique-28 (1.5 × 109 cfu) in sachets. All patients received two sachets of placebo or probiotics twice/day for 15 days and were followed-up for 30 days. The operations were classified as neurosurgical, thoracostomies, laparotomies, orthopedics, and others; then, the SSI and the isolated pathogen were registered. A total of 23 (46.0%) and 13 (24.5%) infectious insults in 89 (50 placebo patients) and 88 (53 probiotics-treated) operations (p = 0.022) were recorded, the majority of them relating to osteosynthesis—17 and 8, respectively. The most commonly identified pathogens were Staphylococcus aureus and Acinetobacter baumannii. Our results support published evidence that the prophylactic administration of probiotics in MT patients exerts a positive effect on the incidence of SSI.
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