ArticleMolecules (Basel, Switzerland)2022
pH-Responsive Hydrogel Beads Based on Alginate, κ-Carrageenan and Poloxamer for Enhanced Curcumin, Natural Bioactive Compound, Encapsulation and Controlled Release Efficiency.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Curcumin improves myocardial redox status in an experimental model of rheumatoid arthritis.Molecular and cellular biochemistry · 2026Article
- Formulation and Analytical Characterization of Phenprocoumon-Loaded κ-Carrageenan Hydrogels for Controlled-Release Applications.Molecules (Basel, Switzerland) · 2026Article
- Structure-property relationships of alginate-protein-polysaccharide composites for encapsulation and controlled release ofFood chemistry: X · 2026Article
- Hydrogel Vehicles for Enteric-Coated Pantoprazole Minitablets: Impact of Polymer Type on Rheology and Drug Release.Gels (Basel, Switzerland) · 2026Article
- pH-Responsive Inulin-Sodium Alginate Hydrogel Beads for Sustained Oral Delivery of Bacterial Serine Protease.Bioengineering (Basel, Switzerland) · 2026Article
- Formulation of Agarose Gels Containing Chitosan-Oleic Acid Complex Particles and Their Physical and In Vitro Digestion Properties.Gels (Basel, Switzerland) · 2026Article
- 3D-Bioprinted Hydrogels Based on Calcium Alginate and Turmeric (ACS omega · 2026Article
- Exploring the beneficial effects of curcumin-based hydrogel beads in rats with rheumatoid arthritis induced by Freund's complete adjuvant.Molecular and cellular biochemistry · 2026Article
- Advances in cellulose-based hydrogels: tunable swelling dynamics and their versatile real-time applications.RSC advances · 2025Review
- Marine-Derived Polysaccharide Hydrogels as Delivery Platforms for Natural Bioactive Compounds.International journal of molecular sciences · 2025Review
- Antibacterial Biocomposite Based on Chitosan/Pluronic/Agarose Noncovalent Hydrogel: Controlled Drug Delivery by Alginate/Tetracycline Beads System.Journal of functional biomaterials · 2024Article
- Natural Polymers as Carriers for Encapsulation of Volatile Oils: Applications and Perspectives in Food Products.Polymers · 2024Review
- LA67 Liposome-Loaded Thermo-Sensitive Hydrogel with Active Targeting for Efficient Treatment of Keloid via Peritumoral Injection.Pharmaceutics · 2023Article
- Design and Development of Low- and Medium-Viscosity Alginate Beads Loaded with PluronicMaterials (Basel, Switzerland) · 2023Article
- One-Step Construction of Tryptophan-Derived Small Molecule Hydrogels for Antibacterial Materials.Molecules (Basel, Switzerland) · 2023Article
- Swelling of Homogeneous Alginate Gels with Multi-Stimuli Sensitivity.International journal of molecular sciences · 2023Article
- Sodium Alginate-Quaternary Polymethacrylate Composites: Characterization of Dispersions and Calcium Ion Cross-Linked Gel Beads.Gels (Basel, Switzerland) · 2022Article
- Article
- Kinetics and Mechanisms ofBioengineering (Basel, Switzerland) · 2022Article
- Article
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6 authors.
Funding
Abstract
Polyphenolic compounds are used for treating various diseases due to their antioxidant and anticancer properties. However, utilization of hydrophobic compounds is limited due to their low bioavailability. In order to achieve a greater application of hydrophobic bioactive compounds, hydrogel beads based on biopolymers can be used as carriers for their enhanced incorporation and controlled delivery. In this study, beads based on the biopolymers-κ-carrageenan, sodium alginate and poloxamer 407 were prepared for encapsulation of curcumin. The prepared beads were characterized using IR, SEM, TGA and DSC. The curcumin encapsulation efficiency in the developed beads was 95.74 ± 2.24%. The release kinetics of the curcumin was monitored in systems that simulate the oral delivery (pH 1.2 and 7.4) of curcumin. The drug release profiles of the prepared beads with curcumin indicated that the curcumin release was significantly increased compared with the dissolution of curcumin itself. The cumulative release of curcumin from the beads was achieved within 24 h, with a final release rate of 12.07% (gastric fluid) as well as 81.93% (intestinal fluid). Both the in vitro and in vivo studies showed that new hydrogel beads based on carbohydrates and poloxamer improved curcumin's bioavailability, and they can be used as powerful carriers for the oral delivery of different hydrophobic nutraceuticals.
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