Evidence map›Paper›PMID 35807269›Full record

ArticleMolecules (Basel, Switzerland)2022

Novel Nitric Oxide Donor Dinitroazetidine-Coumarin Hybrids as Potent Anti-Intrahepatic Cholangiocarcinoma Agents.

Zhihui Yu, Mengru Li, Shiqi Guo, Weijie Wang, Feng Qu, Yulei Ma, Hongrui Liu, Ying Chen

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zhihui YuDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
Mengru LiDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.ORCID 0000-0003-2697-4615
Shiqi GuoDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
Weijie WangDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
Feng QuDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
Yulei MaDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
Hongrui LiuDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.ORCID 0000-0003-3975-8196
Ying ChenDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.ORCID 0000-0002-8197-3108
Fudan University · CN

Funding

Bio-pharmaceutical Research Project of Shanghai Science and Technology Commission 19DZ1910704the Basic Research Field of Shanghai Science and Technology Innovation Action Plan 20JC1419104
6 · The paper itself

Abstract

Intrahepatic cholangiocarcinoma (iCC) is a serious liver cancer threatening human health. However, there are a few chemotherapeutic drugs for the treatment of iCC in the clinic. It is extremely urgent to develop new drugs for iCC. In this study, twenty dinitroazetidine and coumarin hybrids were synthesized and evaluated anti-iCC bioactivity as a new type of nitric oxide (NO) donors. Among them, compounds

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaApoptosisBile Ducts, IntrahepaticCell Line, TumorCell ProliferationCoumarinsHumansNitric Oxide DonorsCoumarinsNitric Oxide Donorsantitumordinitroazetidine-coumarin hybridsintrahepatic cholangiocarcinomaNO donor

Identifiers

PMID35807269
PMCPMC9268168
OpenAlexW4283328001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.