Evidence map›Paper›PMID 35807094›Full record

ArticleJournal of clinical medicine2022

Neuromodulation Using Transcranial Focused Ultrasound on the Bilateral Medial Prefrontal Cortex.

Young Goo Kim, Song E Kim, Jihye Lee, Sungeun Hwang, Seung-Schik Yoo, Hyang Woon Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Young Goo KimDepartments of Neurosurgery, Ewha Womans University Mokdong Hospital, Seoul 07985, Korea.
Song E KimDepartments of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul 07985, Korea.
Jihye LeeDepartments of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul 07985, Korea.
Sungeun HwangDepartments of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul 07985, Korea.ORCID 0000-0003-0813-1315
Seung-Schik YooDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Hyang Woon LeeDepartments of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul 07985, Korea.ORCID 0000-0002-0610-085X
Ewha Womans University · KREwha Womans University Medical Center · KRBrigham and Women's Hospital · US

Funding

Ewha Womans University RP-Grant 2019 and 2021Korea Medical Device Development Foundation KMDF_PR_20200901_0277, NTIS number 1711138909National Research Foundation of Korea No.2020R1A2C2013216, 2019M3C1B8090803, 2019M3C1B8090802
6 · The paper itself

Abstract

Transcranial focused ultrasound (tFUS) is a promising technique of non-invasive brain stimulation for modulating neuronal activity with high spatial specificity. The medial prefrontal cortex (mPFC) has been proposed as a potential target for neuromodulation to prove emotional and sleep qualities. We aim to set up an appropriate clinical protocol for investigating the effects of tFUS stimulation of the bilateral mPFC for modulating the function of the brain-wide network using different sonication parameters. Seven participants received 20 min of 250 kHz tFUS to the bilateral mPFC with excitatory (70% duty cycle with sonication interval at 5 s) or suppressive (5% duty cycle with no interval) sonication protocols, which were compared to a sham condition. By placing the cigar-shaped sonication focus on the falx between both mPFCs, it was possible to simultaneously stimulate the bilateral mPFCs. Brain activity was analyzed using continuous electroencephalographic (EEG) recording during, before, and after tFUS. We investigated whether tFUS stimulation under the different conditions could lead to distinctive changes in brain activity in local brain regions where tFUS was directly delivered, and also in adjacent or remote brain areas that were not directly stimulated. This kind of study setting suggests that dynamic changes in brain cortical responses can occur within short periods of time, and that the distribution of these responses may differ depending on local brain states and functional brain architecture at the time of tFUS administration, or perhaps, at least temporarily, beyond the stimulation time. If so, tFUS could be useful for temporarily modifying regional brain activity, modulating functional connectivity, or reorganizing brain functions associated with various neuropsychiatric diseases, such as insomnia and depression.

Indexed as

excitatorymedial prefrontal cortexmodulationsonication parameterssuppressivetranscranial focused ultrasound

Identifiers

PMID35807094
PMCPMC9267901
OpenAlexW4283760871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.