Evidence map›Paper›PMID 35806986›Full record

ArticleJournal of clinical medicine2022

Dynamic of Serum TWEAK Levels in Critically Ill COVID-19 Male Patients.

Marijana Mikacic, Marko Kumric, Martina Baricevic, Daria Tokic, Sanda Stojanovic Stipic, Ivan Cvitkovic, Daniela Supe Domic, Tina Ticinovic Kurir, Josko Bozic

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Evaluation of the effect of therapeutic plasma exchange on serum cytokine levels in pediatric intensive care unit.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Marijana MikacicIntensive Care Unit of the Department of Internal Medicine, University Hospital of Split, 21000 Split, Croatia.
Marko KumricDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia.ORCID 0000-0002-9696-3359
Martina BaricevicIntensive Care Unit of the Department of Internal Medicine, University Hospital of Split, 21000 Split, Croatia.
Daria TokicDepartment of Anesthesiology and Intensive Care, University Hospital of Split, 21000 Split, Croatia.ORCID 0000-0001-9508-4160
Sanda Stojanovic StipicDepartment of Anesthesiology and Intensive Care, University Hospital of Split, 21000 Split, Croatia.
Ivan CvitkovicDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia.
Daniela Supe DomicDepartment of Health Studies, University of Split, 21000 Split, Croatia.
Tina Ticinovic KurirDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia.
Josko BozicDepartment of Pathophysiology, University of Split School of Medicine, 21000 Split, Croatia.ORCID 0000-0003-1634-0635
University of Split · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the number of cases and mortality of COVID-19 are seemingly declining, clinicians endeavor to establish indicators and predictors of such responses in order to optimize treatment regimens for future outbreaks of SARS-CoV-2 or similar viruses. Considering the importance of aberrant immune response in severe COVID-19, in the present study, we aimed to explore the dynamic of serum TNF-like weak inducer of apoptosis (TWEAK) levels in critically-ill COVID-19 patients and establish whether these levels may predict in-hospital mortality and if TWEAK is associated with impairment of testosterone levels observed in this population. The present single-center cohort study involved 66 men between the ages of 18 and 65 who were suffering from a severe type of COVID-19. Serum TWEAK was rising during the first week after admission to intensive care unit (ICU), whereas decline to baseline values was observed in the second week post-ICU admission (

Indexed as

acute respiratory distress syndromebiomarkerCOVID-19inflammationtestosteroneTWEAK

Identifiers

PMID35806986
PMCPMC9267298
OpenAlexW4283659522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.