ReviewInternational journal of molecular sciences2022
Adipose Tissue Inflammation and Pulmonary Dysfunction in Obesity.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Association between hypertension and impaired lung function among adults: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Assessing the relationship between body mass index and influenza-like illness risk and symptom severity among military health system beneficiaries vaccinated against influenza: a pooled prospective cohort study from a randomized trial.Frontiers in public health · 2026Trial
- Laparoscopic (L-) versus Robotic Assisted (RA-) Roux-en-y Gastric Bypass (RYGB): effects on lung function, respiratory muscle strength, and physical activity after six months.Journal of robotic surgery · 2026Article
- [Clinical characteristics and influencing factors of routine pulmonary ventilation function in children with allergic rhinitis induced by house dust mites].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Therapeutic Potential of Glucagon-like Peptide-1 Receptor Agonists in Respiratory Disorders.International journal of molecular sciences · 2026Review
- Obesity and New-Onset Asthma Risk in Chronic Rhinosinusitis: A Population-Based Cohort Study.Laryngoscope investigative otolaryngology · 2026Article
- Association Between Low Chinese Visceral Adiposity Index Values and Chronic Lung Disease in Older Adults: Cohort Study.JMIR public health and surveillance · 2026Article
- Therapeutic potential of adipose-derived stem cells for noncommunicable diseases.Journal of endocrinological investigation · 2026Review
- Lipid Metabolism and Obesity in Early Life: Drivers of Chronic Lung Disease From Development to Adulthood.Molecular nutrition & food research · 2026Review
- The metabolic code of pulmonary disease: from mechanisms to therapeutic opportunities.Breathe (Sheffield, England) · 2026Review
- Allergic Inflammation Triggers the Unfolded Protein Response andInternational journal of molecular sciences · 2026Article
- Advances in Research on Childhood-Obesity Associated With Gestational Diabetes Mellitus.Journal of diabetes · 2026Review
- The association between birthweight and adult lung function: insights from the UK Biobank.BMC pulmonary medicine · 2026Article
- The age- and sex-specific association between metabolic body composition and lung function: a cross-sectional study.Endocrine journal · 2026Observational
- Spirometric Lung Function Patterns Across Body Mass Index Categories in Ghana: A Tertiary Care Perspective.Pulmonary medicine · 2026Article
- Dietary quality, insulin resistance, and preserved ratio impaired spirometry in postmenopausal women: a cross-sectional study with exploratory mediation analysis.Frontiers in nutrition · 2026Article
- Prognostic Predictors of Bronchial Thermoplasty for Symptom Control in Severe Asthma.Journal of asthma and allergy · 2026Article
- Lunasin alleviates pulmonary inflammation in A549 alveolar epithelial cells and C57BL6/J mice in obese-mimicking conditions.Frontiers in nutrition · 2026Article
- Inflammation-Mediated Causal Effects of MRI-Defined Body-Composition Obesity Axes on Chronic Obstructive Pulmonary Disease, Asthma, and Allergic Rhinitis: A Mendelian Randomization Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Identification and Validation of ALOX15 as a Robust Diagnostic Biomarker for Obesity-Associated Asthma: An Integrative Bioinformatic and Experimental Study.Journal of inflammation research · 2026Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a chronic disease caused by an excess of adipose tissue that may impair health by altering the functionality of various organs, including the lungs. Excessive deposition of fat in the abdominal area can lead to abnormal positioning of the diaphragm and consequent reduction in lung volume, leading to a heightened demand for ventilation and increased exposure to respiratory diseases, such as chronic obstructive pulmonary disease, asthma, and obstructive sleep apnoea. In addition to mechanical ventilatory constraints, excess fat and ectopic deposition in visceral depots can lead to adipose tissue dysfunction, which promotes metabolic disorders. An altered adipokine-secretion profile from dysfunctional adipose tissue in morbid obesity fosters systemic, low-grade inflammation, impairing pulmonary immune response and promoting airway hyperresponsiveness. A potential target of these adipokines could be the NLRP3 inflammasome, a critical component of the innate immune system, the harmful pro-inflammatory effect of which affects both adipose and lung tissue in obesity. In this review, we will investigate the crosstalk between adipose tissue and the lung in obesity, highlighting the main inflammatory mediators and novel therapeutic targets in preventing pulmonary dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.