Evidence map›Paper›PMID 35806280›Full record

ArticleInternational journal of molecular sciences2022

Evaluation of Adverse Effects of Resorbable Hyaluronic Acid Fillers: Determination of Macrophage Responses.

Wim H De Jong, Danyel Jennen, Peter H J Keizers, Hennie M Hodemaekers, Jolanda P Vermeulen, Frank Bakker, Paul Schwillens, Marcel van Herwijnen, Marlon Jetten, Jos C S Kleinjans and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wim H De JongCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.
Danyel JennenDepartment of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, 6200 MD Maastricht, The Netherlands.ORCID 0000-0002-8618-2487
Peter H J KeizersCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.
Hennie M HodemaekersCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.
Jolanda P VermeulenCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.
Frank BakkerCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.
Paul SchwillensCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.
Marcel van HerwijnenDepartment of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, 6200 MD Maastricht, The Netherlands.
Marlon JettenDepartment of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, 6200 MD Maastricht, The Netherlands.ORCID 0000-0001-7500-5613
Jos C S KleinjansDepartment of Toxicogenomics, GROW School for Oncology and Reproduction, Maastricht University, 6200 MD Maastricht, The Netherlands.
Robert E GeertsmaCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.
Rob J VandebrielCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.ORCID 0000-0001-9140-952X

Funding

Health and Youth Care Inspectorate, Ministry of Health, Welfare and Sport, the Netherlands Project V090156Netherlands Organisation for Health Research and Development 80-83900-98-020
6 · The paper itself

Abstract

Resorbable tissue fillers for aesthetic purposes can induce severe complications including product migration, late swelling, and inflammatory reactions. The relation between product characteristics and adverse effects is not well understood. We hypothesized that the degree of cross-linking hyaluronic acid (HA) fillers was associated with the occurrence of adverse effects. Five experimental HA preparations similar to HA fillers were synthesized with an increasing degree of cross-linking. Furthermore, a series of commercial fillers (Perfectha

Indexed as

Dermal FillersHyaluronic AcidBiocompatible MaterialsCytokinesHumansMacrophagesBiocompatible MaterialsCytokinesDermal FillersHyaluronic Acidadverse effectshyaluronic acidmacrophage responsesresorbable fillers

Identifiers

PMID35806280
PMCPMC9266407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.