Evidence map›Paper›PMID 35806193›Full record

ArticleInternational journal of molecular sciences2022

Peripheral Ion Channel Gene Screening in Painful- and Painless-Diabetic Neuropathy.

Milena Ślęczkowska, Rowida Almomani, Margherita Marchi, Bianca T A de Greef, Maurice Sopacua, Janneke G J Hoeijmakers, Patrick Lindsey, Erika Salvi, Gidon J Bönhof, Dan Ziegler and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Genetic Variants Influence the Development of Diabetic Neuropathy.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Peripheral Ion Channel Genes Screening in Painful Small Fiber Neuropathy.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 7 countries.

Milena ŚlęczkowskaDepartment of Toxicogenomics, Maastricht University, 6229 ER Maastricht, The Netherlands.ORCID 0000-0002-7419-523X
Rowida AlmomaniDepartment of Toxicogenomics, Maastricht University, 6229 ER Maastricht, The Netherlands.
Margherita MarchiNeuroalgology Unit, IRCCS Foundation "Carlo Besta" Neurological Institute, 20133 Milan, Italy.
Bianca T A de GreefDepartment of Neurology, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.
Maurice SopacuaDepartment of Neurology, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.ORCID 0000-0001-8132-1532
Janneke G J HoeijmakersDepartment of Neurology, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.ORCID 0000-0001-6940-0027
Patrick LindseyDepartment of Toxicogenomics, Maastricht University, 6229 ER Maastricht, The Netherlands.
Erika SalviNeuroalgology Unit, IRCCS Foundation "Carlo Besta" Neurological Institute, 20133 Milan, Italy.
Gidon J BönhofInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-1446-6592
Dan ZieglerInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0001-8956-3552
Rayaz A MalikDivision of Cardiovascular Sciences, University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0002-7188-8903
Stephen G WaxmanDepartment of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA.
Giuseppe LauriaNeuroalgology Unit, IRCCS Foundation "Carlo Besta" Neurological Institute, 20133 Milan, Italy.
Catharina G FaberDepartment of Neurology, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-2467-067X
Hubert J M SmeetsDepartment of Toxicogenomics, Maastricht University, 6229 ER Maastricht, The Netherlands.
Monique M GerritsDepartment of Clinical Genetics, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-9503-9404
Maastricht University Medical Centre · NLFondazione IRCCS Istituto Neurologico Carlo Besta · ITMaastricht University · NLDeutsches Diabetes-Zentrum e.V. · DEDüsseldorf University Hospital · DEJordan University of Science and Technology · JOUniversity of Manchester · GBVeterans Health Administration · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
European Commission Multi-Center Collaborative Projects through the European Union's Horizon 2020 721841NCATS NIH HHS UL1 TR001863the European Union seventh framework programme for the PROPANE study 602273
6 · The paper itself

Abstract

Neuropathic pain is common in diabetic peripheral neuropathy (DN), probably caused by pathogenic ion channel gene variants. Therefore, we performed molecular inversion probes-next generation sequencing of 5 transient receptor potential cation channels, 8 potassium channels and 2 calcium-activated chloride channel genes in 222 painful- and 304 painless-DN patients. Twelve painful-DN (5.4%) patients showed potentially pathogenic variants (five nonsense/frameshift, seven missense, one out-of-frame deletion) in ANO3 (

Indexed as

Diabetes MellitusDiabetic NeuropathiesNeuralgiaTransient Receptor Potential ChannelsAnoctaminsHumansPotassium ChannelsTRPV Cation ChannelsANO3 protein, humanAnoctaminsKCNK18 protein, humanPotassium ChannelsTransient Receptor Potential ChannelsTRPV Cation Channelsdiabetic neuropathyion channelMIPs-NGSneuropathic painTRP channels

Identifiers

PMID35806193
PMCPMC9266298
OpenAlexW4283693236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.