Evidence map›Paper›PMID 35806187›Full record

ArticleInternational journal of molecular sciences2022

Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK Inhibitors in Pancreatic Cancers.

Boya Li, Yu Feng, Qiaoyun Hou, Yan Fu, Yongzhang Luo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Observational
  5. Review
  6. Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2024
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Boya LiCancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Yu FengCancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Qiaoyun HouCancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Yan FuCancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Yongzhang LuoCancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Tsinghua University · CN

Funding

Self-Topic Fund of Tsinghua University No. 20191080585 and No. 20211080002the Science and Technology Major Project 20181821569
6 · The paper itself

Abstract

Mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors show limited benefit in Kirsten rat sarcoma (

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsATP Binding Cassette Transporter, Subfamily B, Member 2Cell Line, TumorHumansMitogen-Activated Protein Kinase KinasesProtein Kinase InhibitorsProto-Oncogene Proteins p21(ras)ATP Binding Cassette Transporter, Subfamily B, Member 2Mitogen-Activated Protein Kinase KinasesProtein Kinase InhibitorsProto-Oncogene Proteins p21(ras)TAP1 protein, humanABCB2drug resistanceMEK inhibitorPDACTAP1

Identifiers

PMID35806187
PMCPMC9266799
OpenAlexW4283692356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.