Evidence map›Paper›PMID 35806186›Full record

ArticleInternational journal of molecular sciences2022

New 2-[(4-Amino-6-

Łukasz Tomorowicz, Beata Żołnowska, Krzysztof Szafrański, Jarosław Chojnacki, Ryszard Konopiński, Ewa A Grzybowska, Jarosław Sławiński, Anna Kawiak

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Łukasz TomorowiczDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.ORCID 0000-0002-3080-0602
Beata ŻołnowskaDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.ORCID 0000-0003-2007-5168
Krzysztof SzafrańskiDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.ORCID 0000-0001-8347-9659
Jarosław ChojnackiDepartment of Inorganic Chemistry, Faculty of Chemistry, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, Poland.ORCID 0000-0002-2453-8214
Ryszard KonopińskiMaria Skłodowska-Curie National Research Institute of Oncology, ul. Roentgena 5, 02-781 Warszawa, Poland.ORCID 0000-0001-7269-2403
Ewa A GrzybowskaMaria Skłodowska-Curie National Research Institute of Oncology, ul. Roentgena 5, 02-781 Warszawa, Poland.
Jarosław SławińskiDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.ORCID 0000-0003-2794-5031
Anna KawiakDepartment of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, ul. Abrahama 58, 80-307 Gdańsk, Poland.ORCID 0000-0001-8105-2555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the search for new compounds with antitumor activity, new potential anticancer agents were designed as molecular hybrids containing the structures of a triazine ring and a sulfonamide fragment. Applying the synthesis in solution, a base of new sulfonamide derivatives

Indexed as

Antineoplastic AgentsBenzenesulfonatesTriazinesApoptosisCell Line, TumorCell ProliferationDrug DesignDrug Screening Assays, AntitumorHCT116 CellsHumansMCF-7 CellsMolecular StructureStructure-Activity RelationshipSulfonamidesTumor Suppressor Protein p53Antineoplastic AgentsBenzenesulfonatesbenzenesulfonic acidSulfonamidesTriazinesTumor Suppressor Protein p531,3,5-triazinesanticancer activityapoptosisbenzenesulfonamidecell cycle arrestimidazoleproliferationQSARsynthesis

Identifiers

PMID35806186
PMCPMC9267128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.