Evidence map›Paper›PMID 35806175›Full record

ArticleInternational journal of molecular sciences2022

Structural and Biofunctional Insights into the Cyclo(Pro-Pro-Phe-Phe-) Scaffold from Experimental and In Silico Studies: Melanoma and Beyond.

Joanna Bojarska, Martin Breza, Milan Remko, Malgorzata Czyz, Anna Gajos-Michniewicz, Michał Zimecki, Krzysztof Kaczmarek, Izabela D Madura, Jakub M Wojciechowski, Wojciech M Wolf

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Chemical profiling and cytotoxic activity of the endophytic fungus Epicoccum sorghinum isolated from Disynaphia filifolia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
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  11. Antiviral Activity of a Cyclic Pro-Pro-Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Joanna BojarskaInstitute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Zeromskiego Street, 90-924 Lodz, Poland.ORCID 0000-0001-9190-6913
Martin BrezaDepartment of Physical Chemistry, Slovak Technical University, Radlinskeho 9, SK-81237 Bratislava, Slovakia.ORCID 0000-0001-5995-0279
Milan RemkoRemedika, Luzna 9, SK-85104 Bratislava, Slovakia.
Malgorzata CzyzDepartment of Molecular Biology of Cancer, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215 Lodz, Poland.ORCID 0000-0002-8279-4742
Anna Gajos-MichniewiczDepartment of Molecular Biology of Cancer, Medical University of Lodz, 6/8 Mazowiecka Street, 92-215 Lodz, Poland.ORCID 0000-0002-6159-4194
Michał ZimeckiInstitute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla Street, 53-112 Wroclaw, Poland.ORCID 0000-0002-6206-8006
Krzysztof KaczmarekInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Żeromskiego Street, 90-924 Lodz, Poland.ORCID 0000-0001-8806-7792
Izabela D MaduraFaculty of Chemistry, Warsaw University of Technology, 3 Noakowskiego Street, 00-664 Warsaw, Poland.ORCID 0000-0001-5009-2554
Jakub M WojciechowskiRigaku Europe SE, Hugenottenallee 167, 63263 Neu-Isenburg, Germany.
Wojciech M WolfInstitute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Zeromskiego Street, 90-924 Lodz, Poland.
Lodz University of Technology · PLMedical University of Lodz · PLLudwik Hirszfeld Institute of Immunology and Experimental Therapy · PLOcná klinika · SKSlovak University of Technology in Bratislava · SKWarsaw University of Technology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Short peptides have great potential as safe and effective anticancer drug leads. Herein, the influence of short cyclic peptides containing the Pro-Pro-Phe-Phe sequence on patient-derived melanoma cells was investigated. Cyclic peptides such as cyclo(Leu-Ile-Ile-Leu-Val-Pro-Pro-Phe-Phe-), called CLA, and cyclo(Pro-homoPro-β

Indexed as

MelanomaPeptides, CyclicDipeptidesHumansPeptidesDipeptidesPeptidesPeptides, Cyclicphenylalanylphenylalanineprolyl-prolineDFTelectrostatic potentialenergy frameworksHirshfeld surfacehomo amino acidsmelanomashort peptides

Identifiers

PMID35806175
PMCPMC9266943
OpenAlexW4283698330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.