Evidence map›Paper›PMID 35806135›Full record

ArticleInternational journal of molecular sciences2022

Cisplatin-Resistant CD44

Karina Lindbøg Madsen, Oke Gerke, Poul F Høilund-Carlsen, Birgitte Brinkmann Olsen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Karina Lindbøg MadsenDepartment of Nuclear Medicine, Odense University Hospital, DK-5000 Odense, Denmark.
Oke GerkeDepartment of Nuclear Medicine, Odense University Hospital, DK-5000 Odense, Denmark.ORCID 0000-0001-6335-3303
Poul F Høilund-CarlsenDepartment of Nuclear Medicine, Odense University Hospital, DK-5000 Odense, Denmark.ORCID 0000-0001-7420-2367
Birgitte Brinkmann OlsenDepartment of Nuclear Medicine, Odense University Hospital, DK-5000 Odense, Denmark.ORCID 0000-0002-6130-0387
University of Southern Denmark · DK

Funding

Aase and Ejnar Danielsen's Foundation NABrdr. Hartmann Foundation NADesirée and Niels Ydes Foundation NADirector Emil C. Hertz and wife Inger Hertz' Foundation NAEinar Willumsens Memorial Foundation NAEva and Henry Fraenkels Memorial Foundation NAFrode Nygaards Foundation NAKaren S. Jensens Foundation NAOdense University Hospital Research Council NASimon Fougner Hartmanns family Foundation NAthe Hede Nielsen family Foundation NAThe Independent Research Fund Denmark, Technology and Production 7017‑00303
6 · The paper itself

Abstract

Cancer stem cells (CSCs) are resistant to conventional therapy and present a major clinical challenge since they are responsible for the relapse of many cancers, including non-small cell lung cancer (NSCLC). Hence, future successful therapy should also eradicate CSCs. Auger electrons have demonstrated promising therapeutic potential and can induce DNA damage while sparing surrounding cells. Here, we sort primary patient-derived NSCLC cells based on their expression of the CSC-marker CD44 and investigate the effects of cisplatin and a thymidine analog (deoxyuridine) labeled with an Auger electron emitter (

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsCell Line, TumorCisplatinDeoxyuridineElectronsHumansHyaluronan ReceptorsNeoplasm Recurrence, LocalNeoplastic Stem CellsThymidineCD44 protein, humanCisplatinDeoxyuridineHyaluronan ReceptorsThymidineapoptosisauger electronscancer stem cellsCD44cisplatinDNA damagelung cancer

Identifiers

PMID35806135
PMCPMC9266901
OpenAlexW4283657847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.