Evidence map›Paper›PMID 35806068›Full record

ArticleInternational journal of molecular sciences2022

Scorpion Neurotoxin Syb-prII-1 Exerts Analgesic Effect through Nav1.8 Channel and MAPKs Pathway.

Fei Bai, Yongbo Song, Yi Cao, Mengqi Ban, Zhenyu Zhang, Yang Sun, Yuan Feng, Chunli Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fei BaiDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yongbo SongDepartment of Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yi CaoDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Mengqi BanDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhenyu ZhangDepartment of Biochemistry, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yang SunDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yuan FengDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.
Chunli LiDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.

Funding

National Natural Science Foundation of China 81073081, 81973227National Science and Technology Major Project of the Ministry of Science and Technology of China 2018ZX09735005Research Foundation of Education Bureau of Liaoning province 2019LZD02Scientific Research Staring Foundation for the Returned Overseas Scholars, Shenyang Pharmaceutical University GGJJ2021101
6 · The paper itself

Abstract

Trigeminal neuralgia (TN) is a common type of peripheral neuralgia in clinical practice, which is usually difficult to cure. Common analgesic drugs are difficult for achieving the desired analgesic effect. Syb-prII-1 is a β-type scorpion neurotoxin isolated from the scorpion venom of

Indexed as

Scorpion VenomsTrigeminal NeuralgiaAnalgesicsAnimalsMitogen-Activated Protein KinasesNeurotoxinsRatsRats, Sprague-DawleyScorpionsAnalgesicsMitogen-Activated Protein KinasesNeurotoxinsScorpion VenomsBmKIoN-CCI modelMAPKs pathwayNav1.8Nav1.9Syb-prII-1trigeminal neuralgiaVGSCsVSD2rNav1.8β-type scorpion neurotoxin

Identifiers

PMID35806068
PMCPMC9266357

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.