Evidence map›Paper›PMID 35806049›Full record

ArticleInternational journal of molecular sciences2022

Amitriptyline Accelerates SERT Binding Recovery in a Rat 3,4-Methylenedioxymethamphetamine (MDMA) Model: In Vivo 4-[

Chi-Jung Tsai, Chuang-Hsin Chiu, Yu-Yeh Kuo, Wen-Sheng Huang, Tsung-Hsun Yu, Leo Garcia Flores, Skye Hsin-Hsien Yeh, Kuo-Hsing Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Chi-Jung TsaiDepartment of Nuclear Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.
Chuang-Hsin ChiuDepartment of Nuclear Medicine, Tri-Service General Hospital, Taipei 114, Taiwan.ORCID 0000-0002-7275-6558
Yu-Yeh KuoDepartment of Nursing, Hsin-Sheng College of Medical Care and Management, Taoyuan 325, Taiwan.
Wen-Sheng HuangDepartment of Nuclear Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.
Tsung-Hsun YuBrain Research Center, National Yang Ming Chaio Tung University, Taipei 112, Taiwan.
Leo Garcia FloresRadiomedix, Inc., Houston, TX 77042, USA.
Skye Hsin-Hsien YehBrain Research Center, National Yang Ming Chaio Tung University, Taipei 112, Taiwan.ORCID 0000-0002-7495-1146
Kuo-Hsing MaDepartment of Biology and Anatomy, National Defense Medi Center, Taipei 110, Taiwan.
National Yang Ming Chiao Tung University · TWTaipei Medical University Hospital · TWHsin Sheng College of Medical Care and Management · TWNational Defense Medical Center · TWRadioMedix (United States) · USTri-Service General Hospital · TW

Funding

Development Center for Biotechnology 110M0156Ministry of Science and Technology R.O.C. MOST-109-2314-B-038-151, MOST-110-2314-B-A49A-528, 109-2314-B-016-014-MY2
6 · The paper itself

Abstract

Numerous studies have confirmed that 3,4-Methylenedioxymethamphetamine (MDMA) produces long-lasting changes to the density of the serotonin reuptake transporter (SERT). Amitriptyline (AMI) has been shown to exert neuroprotective properties in neuropathologic injury. Here, we used a SERT-specific radionuclide, 4-[

Indexed as

Neuroprotective AgentsN-Methyl-3,4-methylenedioxyamphetamineAmitriptylineAnimalsBrainFluorine RadioisotopesPositron-Emission TomographyRatsSerotonin Plasma Membrane Transport ProteinsAmitriptylineFluorine-18Fluorine RadioisotopesNeuroprotective AgentsN-Methyl-3,4-methylenedioxyamphetamineSerotonin Plasma Membrane Transport Proteins4-[18F]-ADAMamitriptylineMDMASERT

Identifiers

PMID35806049
PMCPMC9266335
OpenAlexW4283573862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.