Evidence map›Paper›PMID 35805966›Full record

ArticleInternational journal of molecular sciences2022

miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium.

Natasa Djalinac, Ewald Kolesnik, Heinrich Maechler, Susanne Scheruebel-Posch, Brigitte Pelzmann, Peter P Rainer, Ines Foessl, Markus Wallner, Daniel Scherr, Akos Heinemann and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases.Journal of cardiovascular development and disease · 2023
    Review
  3. Editorial for Special Issue: "MicroRNA in Cardiac Health and Disease".International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 4 countries.

Natasa DjalinacDepartment of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria.
Ewald KolesnikDepartment of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-9349-8068
Heinrich MaechlerDepartment of Cardiothoracic Surgery, Medical University of Graz, 8036 Graz, Austria.
Susanne Scheruebel-PoschGottfried Schatz Research Center, Institute of Biophysics, Medical University of Graz, 8010 Graz, Austria.
Brigitte PelzmannGottfried Schatz Research Center, Institute of Biophysics, Medical University of Graz, 8010 Graz, Austria.
Peter P RainerDepartment of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-2840-6454
Ines FoesslDepartment of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, Austria.
Markus WallnerDepartment of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-7692-892X
Daniel ScherrDepartment of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria.
Akos HeinemannInstitute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-8554-2372
Simon SedejDepartment of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-4419-6821
Senka Ljubojevic-HolzerDepartment of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-6994-9976
Dirk von LewinskiDepartment of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria.
Egbert BispingDepartment of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria.
Medical University of Graz · ATUniversity of Padua · IT

Funding

FWF Austrian Science Fund V 530
6 · The paper itself

Abstract

Many cardiac insults causing atrial remodeling are linked to either stretch or tachycardia, but a comparative characterization of their effects on early remodeling events in human myocardium is lacking. Here, we applied isometric stretch or sustained tachycardia at 2.5 Hz in human atrial trabeculae for 6 h followed by microarray gene expression profiling. Among largely independent expression patterns, we found a small common fraction with the microRNA miR-1183 as the highest up-regulated transcript (up to 4-fold). Both, acute stretch and tachycardia induced down-regulation of the predicted miR-1183 target genes

Indexed as

Atrial FibrillationAtrial RemodelingMicroRNAsBiomarkersHumansMyocardiumTachycardiaBiomarkersMicroRNAsMIRN1183 microRNA, humanbiomarkercardiac remodelinghuman myocardiummicroRNAmiR-1183MIR1183stretchtachycardia

Identifiers

PMID35805966
PMCPMC9266684
OpenAlexW4283381751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.