Evidence map›Paper›PMID 35805910›Full record

ReviewInternational journal of molecular sciences2022

Evaluating Enzymatic Productivity-The Missing Link to Enzyme Utility.

Khawar Sohail Siddiqui, Haluk Ertan, Anne Poljak, Wallace J Bridge

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Screening and Characterization of MarineMolecules (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Improving the Thermostability ofInternational journal of molecular sciences · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Screening and Characteristics of MarineMolecules (Basel, Switzerland) · 2022
    Article
  17. A New Phospholipase D fromInternational journal of molecular sciences · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Khawar Sohail SiddiquiSchool of Biotechnology and Biomolecular Sciences (BABS), The University of New South Wales (UNSW), Kensington, Sydney, NSW 2052, Australia.ORCID 0000-0001-8574-3177
Haluk ErtanSchool of Chemical Engineering, The University of New South Wales (UNSW), Kensington, Sydney, NSW 2052, Australia.
Anne PoljakMark Wainwright Analytical Centre, The University of New South Wales (UNSW), Kensington, Sydney, NSW 2052, Australia.
Wallace J BridgeSchool of Biotechnology and Biomolecular Sciences (BABS), The University of New South Wales (UNSW), Kensington, Sydney, NSW 2052, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kinetic productivity analysis is critical to the characterization of enzyme catalytic performance and capacity. However, productivity analysis has been largely overlooked in the published literature. Less than 0.01% of studies which report on enzyme characterization present productivity analysis, despite the fact that this is the only measurement method that provides a reliable indicator of potential commercial utility. Here, we argue that reporting productivity data involving native, modified, and immobilized enzymes under different reaction conditions will be of immense value in optimizing enzymatic processes, with a view to accelerating biotechnological applications. With the use of examples from wide-ranging studies, we demonstrate that productivity is a measure of critical importance to the translational and commercial use of enzymes and processes that employ them. We conclude the review by suggesting steps to maximize the productivity of enzyme catalyzed reactions.

Indexed as

BiotechnologyEnzymes, ImmobilizedBiocatalysisCatalysisKineticsEnzymes, Immobilizedbiocatalysischemical modificationenzymegenetic modificationimmobilizedindustrial biotechnologyinhibitionkineticsproductivitystability

Identifiers

PMID35805910
PMCPMC9266678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.