ArticleInternational journal of environmental research and public health2022
Point-of-Care Diagnostics for Diagnosis of Active Syphilis Infection: Needs, Challenges and the Way Forward.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Sexually transmitted infection prevalence and testing coverage among people who inject drugs: A systematic review.Drug and alcohol dependence · 2025Pooled it
- Improved rapid diagnostic tests to detect syphilis and yaws: a systematic review and meta-analysis.Sexually transmitted infections · 2022Pooled it
- Utilization and Performance of a Rapid Treponemal Antibody Test for Diagnosis of Syphilis in a High-Risk Population at an Urban County Hospital.Sexually transmitted diseases · 2026Article
- High prevalence of syphilis in Australia: test, treat and trace.Australian prescriber · 2026Review
- Estimating the Value of Novel Tests for Active Syphilis in Zimbabwe: How Much Overtreatment Can Be Avoided?Sexually transmitted diseases · 2026Article
- Strengthening STD Screening Programs: Comprehensive Evaluation of High-Throughput Immunoassays for HIV and Syphilis Detection.Microorganisms · 2026Article
- Updates on epidemiology and diagnostic tests of syphilis in South Korea.The Korean journal of internal medicine · 2026Review
- Difficulties with clinical practice guidelines for congenital syphilis prevention in Colombia: a qualitative study.BMC infectious diseases · 2026Article
- Review
- Technological innovations and breakthrough pathways in syphilis diagnosis: addressing global resurgence and the journey toward elimination.Frontiers in cellular and infection microbiology · 2026Review
- Clinical development and performance of the First to Know Syphilis Self-Test for over-the-counter usage: aJournal of clinical microbiology · 2025Article
- Advances in Syphilis Diagnostics to Address the 21st-Century Epidemic.Clinical chemistry · 2025Review
- Point-of-Care Syphilis Testing: Implementation and Future Direction.Current HIV/AIDS reports · 2025Review
- Update on syphilis diagnostics.Current opinion in infectious diseases · 2025Review
- Evaluation of whole-genome enrichment and sequencing ofiScience · 2024Article
- Research of Combined ES-BP Model in Predicting Syphilis Incidence 1982-2020 in Mainland China.Iranian journal of public health · 2023Article
- Advantages and limitations of current diagnostic laboratory approaches in syphilis and congenital syphilis.Expert review of anti-infective therapyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syphilis, a curable sexually transmitted infection, has re-emerged as a global public health threat with an estimated 5.6 million new cases every year. Pregnant women and men who have sex with men are key target populations for syphilis control and prevention programs. Frequent syphilis testing for timely and accurate diagnosis of active infections for appropriate clinical management is a key strategy to effectively prevent disease transmission. However, there are persistent challenges in the diagnostic landscape and service delivery/testing models that hinder global syphilis control efforts. In this commentary, we summarise the current trends and challenges in diagnosis of active syphilis infection and identify the data gaps and key areas for research and development of novel point-of-care diagnostics which could help to overcome the present technological, individual and structural barriers in access to syphilis testing. We present expert opinion on future research which will be required to accelerate the validation and implementation of new point-of-care diagnostics in real-world settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.