Evidence map›Paper›PMID 35805773›Full record

ArticleInternational journal of environmental research and public health2022

The Potential Key Role of the NRF2/NQO1 Pathway in the Health Effects of Arsenic Pollution on SCC.

Qianlei Yang, Rui Yan, Yuemei Mo, Haixuan Xia, Hanyi Deng, Xiaojuan Wang, Chunchun Li, Koichi Kato, Hengdong Zhang, Tingxu Jin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Qianlei YangDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, China.
Rui YanDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, China.
Yuemei MoPhysical Examination Department, Center for Disease Control and Prevention of Suzhou Industrial Park, Suzhou 215100, China.
Haixuan XiaDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, China.
Hanyi DengShanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
Xiaojuan WangDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, China.
Chunchun LiChangzhou Wujin District Center for Disease Control and Prevention, Changzhou 213164, China.
Koichi KatoLaboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon University, Chiba 274-8555, Japan.
Hengdong ZhangDepartment of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China.
Tingxu JinDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, China.ORCID 0000-0002-1491-9259
Jie ZhangDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, China.
Yan AnDepartment of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, China.ORCID 0000-0003-2838-8169
Soochow University · CNChinese Preventive Medicine Association · CNGuiyang Medical University · CNNanjing Municipal Center for Disease Control And Prevention · CNNihon University · JPShanghai Municipal Center For Disease Control Prevention · CNSuzhou Municipal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arsenic is widely present in nature and is a common environmental poison that seriously damages human health. Chronic exposure to arsenic is a major environmental poisoning factor that promotes cell proliferation and leads to malignant transformation. However, its molecular mechanism remains unclear. In this study, we found that arsenite can promote the transformation of immortalized human keratinocyte cells (HaCaT) from the G0/G1 phase to S phase and demonstrated malignant phenotypes. This phenomenon is accompanied by obviously elevated levels of NRF2, NQO1, Cyclin E, and Cyclin-dependent kinase 2 (CDK2). Silencing the NRF2 expression with small interfering RNA (siRNA) in arsenite-transformed (T-HaCaT) cells was shown to reverse the malignant phenotype. Furthermore, the siRNA silencing of

Indexed as

ArsenicArsenitesCell LineCell Transformation, NeoplasticCyclin EHumansKeratinocytesNAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2RNA, Small InterferingArsenicArsenitesCyclin ENAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2NQO1 protein, humanRNA, Small Interferingarsenite pollutioncell proliferationhealth effectmalignant transformationNRF2/NQO1 pathwaysquamous cell carcinoma

Identifiers

PMID35805773
PMCPMC9265438
OpenAlexW4283793761

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.