Evidence map›Paper›PMID 35805759›Full record

ArticleInternational journal of environmental research and public health2022

Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms.

Gabriele Grunig, Nedim Durmus, Yian Zhang, Yuting Lu, Sultan Pehlivan, Yuyan Wang, Kathleen Doo, Maria L Cotrina-Vidal, Roberta Goldring, Kenneth I Berger and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Gabriele GrunigDepartment of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA.ORCID 0000-0002-1846-6322
Nedim DurmusDivision of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Yian ZhangWorld Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA.
Yuting LuWorld Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA.
Sultan PehlivanDivision of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Yuyan WangWorld Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA.ORCID 0000-0003-3747-0762
Kathleen DooPulmonary, Kaiser Permanente East Bay, Oakland, CA 94611, USA.
Maria L Cotrina-VidalDivision of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Roberta GoldringDivision of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Kenneth I BergerDivision of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Mengling LiuWorld Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA.
Yongzhao ShaoDepartment of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA.
Joan ReibmanDepartment of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA.
New York City Health and Hospitals Corporation · USNew York University · USKaiser Permanente · US

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Uncovering Alzheimer's disease risk mechanisms through neuron-specific analysis of autophagy and endosomal-lysosomal functionP01AG017617 · NIA · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI NIXON, RALPH A. · 2000 to 2021
$40.0M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELIKOFF, JUDITH TERRY · 1985 to 2020
$26.1M
WORLD TRADE CENTER REGISTRYU50TS272750 · TS · NEW YORK CITY HEALTH/MENTAL HYGIENE · PI FARFEL, MARK R · 2005 to 2008
$12.3M
Uncontrolled Lower Respiratory Symptoms in the WTC Survivor ProgramU01OH010404 · OH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REIBMAN, JOAN · 2013 to 2015
$2.7M
ATSDR CDC HHS U50 TS272750NCATS NIH HHS UL1 TR001445NIA NIH HHS P01 AG017617NIEHS NIH HHS P30 ES000260NIOSH CDC HHS U01 OH010404NIOSH CDC HHS U01 OH012486NIOSH CDC HHS U50 OH009739
6 · The paper itself

Abstract

The destruction of the World Trade Center (WTC) on September 11, 2001 (9/11) released large amounts of toxic dusts and fumes into the air that exposed many community members who lived and/or worked in the local area. Many community members, defined as WTC survivors by the federal government, developed lower respiratory symptoms (LRS). We previously reported the persistence of these symptoms in patients with normal spirometry despite treatment with inhaled corticosteroids and/or long-acting bronchodilators. This report expands upon our study of this group with the goal to identify molecular markers associated with exposure and heterogeneity in WTC survivors with LRS using a selected plasma biomarker approach. Samples from WTC survivors with LRS (

Indexed as

September 11 Terrorist AttacksBiomarkersCluster AnalysisDustHumansNew York CityReceptor for Advanced Glycation End ProductsBiomarkersDustReceptor for Advanced Glycation End Productsirritant induced asthmalower respiratory symptomsmolecular biomarkerspersistent respiratory symptoms following exposuresplasma biomarkersSeptember 11 2001 disasterWorld Trade Center exposure

Identifiers

PMID35805759
PMCPMC9266229
OpenAlexW4283773929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.