Evidence map›Paper›PMID 35805411›Full record

SynthesisInternational journal of environmental research and public health2022

Mycotoxin-Linked Mutations and Cancer Risk: A Global Health Issue.

Theodora Ekwomadu, Mulunda Mwanza, Alfred Musekiwa

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Guangdong Biobank Cohort (GDBC) study.European journal of epidemiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Theodora EkwomaduFood Security and Safety Niche Area, Department of Animal Health, Mafikeng Campus, Northwest University, Mmabatho 2735, South Africa.ORCID 0000-0002-4228-3163
Mulunda MwanzaFood Security and Safety Niche Area, Department of Animal Health, Mafikeng Campus, Northwest University, Mmabatho 2735, South Africa.ORCID 0000-0002-9311-6517
Alfred MusekiwaDivision of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University & Tygerberg Hospital, Cape Town 7505, South Africa.ORCID 0000-0001-5880-3680

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans continue to be constantly exposed to mycotoxins, mainly through oral exposure (dietary), inhalation, or dermal contact. Recently, it has been of increasing interest to investigate mycotoxin-linked carcinogenicity. This systematic review was conducted to synthesize evidence of the association between mycotoxin-linked mutations and the risk of cancer, to provide an overview of the data linking exposure to different mycotoxins with human cancer risk, and to provide an update on current research on the risk of cancer associated with human exposure to mycotoxins. PRISMA guidelines were used when conducting the systematic review. PubMed, MEDLINE, and CINAHL electronic databases were comprehensively searched to extract the relevant studies published from inception to May 2022. A total of sixteen relevant studies (4907 participants) were identified and included in this review. Of these, twelve studies were from Asia, while four of the studies were conducted in Africa. The overall meta-analysis result found no significant association, although some of the studies confirmed an association between mycotoxin-linked mutations and primary liver cancer risk. Mainly, the experimental studies have shown associations between mycotoxin-linked mutations and cancer risk, and there is a need for researchers to confirm these links in epidemiological studies in order to guide public health policies and interventions.

Indexed as

MycotoxinsNeoplasmsAfricaDietFood ContaminationGlobal HealthHumansMutationMycotoxinsaflatoxincancerexposurefoodfumonisinfungal metabolitesmutationmycotoxins

Identifiers

PMID35805411
PMCPMC9266006

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.