Evidence map›Paper›PMID 35805192›Full record

ArticleCells2022

CaMKII Inhibition Attenuates Distinct Gain-of-Function Effects Produced by Mutant Nav1.6 Channels and Reduces Neuronal Excitability.

Agnes S Zybura, Firoj K Sahoo, Andy Hudmon, Theodore R Cummins

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Voltage-Gated NaLife (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Agnes S ZyburaProgram in Medical Neuroscience, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Firoj K SahooDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Andy HudmonDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Theodore R CumminsProgram in Medical Neuroscience, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Purdue University West Lafayette · USIndiana University – Purdue University Indianapolis · USUniversity of Indianapolis · US

Funding

Project 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L. · 2018 to 2022
$12.1M
Sodium channels and electrogenesis in sensory neuronsR01NS053422 · NINDS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CUMMINS, THEODORE R · 2006 to 2019
$4.6M
NINDS NIH HHS R01 NS053422NINDS NIH HHS U54 NS108874
6 · The paper itself

Abstract

Aberrant Nav1.6 activity can induce hyperexcitability associated with epilepsy. Gain-of-function mutations in the

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2EpilepsyGain of Function MutationHumansNeuronsPatch-Clamp TechniquesCalcium-Calmodulin-Dependent Protein Kinase Type 2CaMKIIelectrophysiologyNav1.6phosphorylationpost-translational modification (PTM)sodium channel

Identifiers

PMID35805192
PMCPMC9266207
OpenAlexW4283790846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.