Evidence map›Paper›PMID 35805190›Full record

ArticleCells2022

Selective Ablation of BCL11A in Epidermal Keratinocytes Alters Skin Homeostasis and Accelerates Excisional Wound Healing In Vivo.

Nilika Bhattacharya, Arup K Indra, Gitali Ganguli-Indra

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. eIF6 modulates skin wound healing by upregulating keratin 6B.Stem cells translational medicine · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nilika BhattacharyaDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
Arup K IndraDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0001-6137-7555
Gitali Ganguli-IndraDepartment of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
Oregon State University · US

Funding

Mechanisms of Ctip2-regulated contribution of hair stem cells to skin woundsR15AR068584 · NIAMS · OREGON STATE UNIVERSITY · PI INDRA, GITALI · 2015 to 2015
$380k
NIAMS NIH HHS R15 AR068584
6 · The paper itself

Abstract

Transcriptional regulator BCL11A plays a crucial role in coordinating a suite of developmental processes including skin morphogenesis, barrier functions and lipid metabolism. There is little or no reports so far documenting the role of BCL11A in postnatal adult skin homeostasis and in the physiological process of tissue repair and regeneration. The current study establishes for the first time the In Vivo role of epidermal BCL11A in maintaining adult epidermal homeostasis and as a negative regulator of cutaneous wound healing. Conditional ablation of

Indexed as

EpidermisKeratinocytesAnimalsHomeostasisMiceRepressor ProteinsSkinTranscription FactorsWound HealingBcl11a protein, mouseRepressor ProteinsTranscription FactorsB-cell CLL/lymphoma 11 A (BCL11A)cell/non-cell autonomouschicken ovalbumin upstream promoter transcription factor (COUP-TF) interacting protein 1differentiationepidermal homeostasisepidermal permeability barrierepidermis specific deletionexcisional wound healinghair follicleinterfollicular epidermisIn Vivokeratinocyte activationre-epithelializationtranscription factor

Identifiers

PMID35805190
PMCPMC9265695
OpenAlexW4283790920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.