Evidence map›Paper›PMID 35805002›Full record

ArticleCancers2022

Iron Chelator VLX600 Inhibits Mitochondrial Respiration and Promotes Sensitization of Neuroblastoma Cells in Nutrition-Restricted Conditions.

Amanda Westergren Jakobsson, Snehangshu Kundu, Jing Guo, Azazul Chowdhury, Miao Zhao, Emma Lindell, Peter Bergsten, Fredrik J Swartling, Tobias Sjöblom, Xiaonan Zhang

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Amanda Westergren JakobssonDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
Snehangshu KunduDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.ORCID 0000-0003-3541-5583
Jing GuoCentre for Computational Biology, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Azazul ChowdhuryDepartment of Medical Cell Biology, Uppsala University, BMC, Husargatan 3, SE-75123 Uppsala, Sweden.
Miao ZhaoDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
Emma LindellDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
Peter BergstenDepartment of Medical Cell Biology, Uppsala University, BMC, Husargatan 3, SE-75123 Uppsala, Sweden.
Fredrik J SwartlingDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.ORCID 0000-0002-8460-4367
Tobias SjöblomDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.ORCID 0000-0001-6668-4140
Xiaonan ZhangDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.ORCID 0000-0003-4359-9079
Uppsala University · SEDuke-NUS Medical School · SG

Funding

Barncancerfonden PR2020-0079Barncancerfonden TJ2021-0111Jeansson Foundations 000000
6 · The paper itself

Abstract

Neuroblastoma, the most common solid tumor in children, is characterized by amplification of the

Indexed as

mitochondriamTORMYCNneuroblastomanew therapeutic approachspheroids

Identifiers

PMID35805002
PMCPMC9264775
OpenAlexW4283743697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.